SEARCH

SEARCH BY CITATION

FilenameFormatSizeDescription
trf12771-sup-0001-as1.pdf80K

Appendix S1. Supplemental method.

trf12771-sup-0002-fs1.pdf24K

Fig. S1. Structures and biosynthetic pathways of the blood group P1, Pk, and related antigens. The carbohydrate chains bearing the antigenic determinants of these blood groups are linked to ceramide (Cer) on the cell membrane. The blood group P1 and Pk antigens, synthesized through distinct biosynthetic routes, are both determined by the enzymatic activity of the α4GalT encoded from the A4GALT gene. The Pk antigen is the precursor for the globoside series of antigens, including the blood group antigens P, Forssman, LKE (also called stage-specific embryonic antigen-4 [SSEA-4]), and NOR. The NOR antigens, NOR1 and NOR2, are determined by the A4GALT gene with a C631G missense mutation, which encodes an α4GalT with altered acceptor specificity; these comprise the third antigen, after the P1 and Pk antigens, in the P1PK blood group system.

trf12771-sup-0003-ts1.pdf154K

Table S1. PCR primers for the SNP analysis

trf12771-sup-0004-ts2.pdf97K

Table S2. Nucleotide genotypes of the 416 different SNP sites in the A4GALT gene of four P1 and four P2 Taiwanese*

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.