Effect of maropitant, a neurokinin-1 receptor antagonist, on the minimum alveolar concentration of sevoflurane during stimulation of the ovarian ligament in cats
Article first published online: 13 FEB 2013
© 2013 The Authors. Veterinary Anaesthesia and Analgesia © 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia
Veterinary Anaesthesia and Analgesia
Volume 40, Issue 4, pages 425–431, July 2013
How to Cite
Niyom, S., Boscan, P., Twedt, D. C., Monnet, E. and Eickhoff, J. C. (2013), Effect of maropitant, a neurokinin-1 receptor antagonist, on the minimum alveolar concentration of sevoflurane during stimulation of the ovarian ligament in cats. Veterinary Anaesthesia and Analgesia, 40: 425–431. doi: 10.1111/vaa.12017
- Issue published online: 13 JUN 2013
- Article first published online: 13 FEB 2013
- Manuscript Accepted: 31 MAR 2012
- Manuscript Received: 23 JAN 2012
- Winn Feline Foundation
- minimum alveolar concentration;
- neurokinin-1 receptor;
Determine if maropitant decreases the minimum alveolar concentration (MAC) of sevoflurane during stimulation of the ovarian ligament in cats.
Fifteen, female cats weighing 2.5 ± 0.6kg (mean ± SD).
Anesthesia was induced and maintained with sevoflurane. The right ovary was accessed via laparoscopy. A suture around the ovary and ovarian ligament was exteriorized through the abdominal wall for stimulation. A stimulus–response curve was created to identify the optimal force for MAC comparisons. In 10 cats, MAC was determined with only sevoflurane (baseline) then after 1 and 5 mg kg−1 intravenous maropitant administration. The stimulation tension force used was 4.9 N. Repeated measures anova was used to compare the groups. MAC was defined as the average of the cross-over concentrations and reported MAC is adjusted to sea-level and depicted as mean ± SD.
The stimulus-response curve was hyperbolic and plateaued at 4.3 ± 3 N. The optimal tension force chosen to compare MAC was 4.9 N. The baseline sevoflurane MAC was 2.96 ± 0.3%. Maropitant, 1 mg kg−1, decreased the MAC to 2.51 ± 0.3% (15%, p < 0.01). The higher maropitant dose of 5 mg kg−1 did not change MAC further when compared to the low dose (2.46 ± 0.4%, p = 0.33).
Conclusion and clinical relevance
The ovarian ligament stimulation model is suitable to determine MAC during visceral stimulation in cats. Maropitant decreased the anesthetic requirements during visceral ovarian and ovarian ligament stimulation in cats. Maropitant (1 mg kg−1) decreases MAC by 15%; a higher dose had no additional effect.