A systematic review of sevoflurane and isoflurane minimum alveolar concentration in domestic cats

Authors

  • Mike R Shaughnessy,

    1. Veterinary Teaching Hospital, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
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  • Erik H Hofmeister

    Corresponding author
    1. Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
    • Correspondence: Erik Hofmeister, Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens 30602, GA, USA. E-mail: kaastel@gmail.com

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Abstract

Objective

The purpose of this systematic review is to summarize the results of studies which have determined the minimum alveolar concentration (MAC) of isoflurane and sevoflurane in domestic cats.

Study Design

Systematic review.

Animals

Cats.

Methods used

A comprehensive search of research literature was performed without language restriction. The search utilized the Pubmed, Google Scholar, and CAB Abstracts electronic databases using a combination of free text terms ‘Minimum alveolar concentration’, ‘sevoflurane’, ‘isoflurane’, ‘anesthetic’, ‘cat’, ‘cats’ or ‘feline’. The search was conducted from November 2010 to June 2012.

Results

The MAC for isoflurane ranged from 1.20 ± 0.13% to 2.22 ± 0.35% and the MAC for sevoflurane ranged from 2.5 ± 0.2% to 3.95 ± 0.33%. The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%.

Conclusions & Clinical Relevance

The average MAC for isoflurane was 1.71 ± 0.07% and for sevoflurane was 3.08 ± 0.4%. Methodology differed among studies, and particular attention should be paid in the future to appropriate reporting of methods to allow sound conclusions to be made from the results.

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