Electrocardiographic evaluation of the degree of sedation and the isolated use of methadone in healthy dogs
Article first published online: 30 SEP 2013
© 2013 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesia and Analgesia
Veterinary Anaesthesia and Analgesia
Volume 41, Issue 1, pages 97–104, January 2014
How to Cite
Menegheti, T. M., Wagatsuma, J. T., Pacheco, A. D., Perez, B., Pacheco, C. M., Abimussi, C. J., dos Santos, P. P. and de Souza Oliva, V. N. (2014), Electrocardiographic evaluation of the degree of sedation and the isolated use of methadone in healthy dogs. Veterinary Anaesthesia and Analgesia, 41: 97–104. doi: 10.1111/vaa.12086
- Issue published online: 17 DEC 2013
- Article first published online: 30 SEP 2013
- Manuscript Accepted: 30 SEP 2012
- Manuscript Received: 31 MAY 2012
Vol. 41, Issue 2, 162, Article first published online: 24 FEB 2014
- cardiac arrhythmias;
The present study aimed to investigate the influence of methadone on cardiorespiratory parameters, electrocardiogram and clinical sedation in dogs. Further possible side effects are reported.
Prospective experimental cross-over study.
Eight, 1–4-year-old, various breeds of dogs of both genders weighing 9–36 kg.
Each dog was treated three times: methadone 0.3 mg kg−1 (M0.3), 0.5 mg kg−1 (M0.5) and 1.0 mg kg−1 (M1.0) intramuscularly. Respiratory rate, heart rate and arterial blood pressure were recorded as well as electrocardiographic evaluation of lead II. Clinical sedation in each treatment received a score (0–3) after drug administration and at 30 minute intervals until scores and measurements returned to baseline values.
A significant decrease in heart rate was seen with each dose of methadone and bradycardia (HR<60 bpm) was noted in a few dogs at each dose. A clinically significant arrhythmia occurred in one dog at 1 mg kg−1 that required reversal with butorphanol. There was no significant difference in SAP, MAP and DAP between treatments. Some side effects such as salivation, defecation, vocalization and panting, after administration of methadone were observed. There were no differences in mean values of heart rate, P-wave and QRS complex duration and QT interval between treatments.
Conclusion and clinical relevance
Methadone administration was associated with panting and a decrease in heart rate at all doses tested in this study. The cardiac rhythm should be monitored carefully in dogs when methadone is administered on its own, especially at higher doses.