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Aggressive local therapy combined with systemic chemotherapy provides long-term control in grade II stage 2 canine mast cell tumour: 21 cases (1999–2012)

Authors

  • A. Lejeune,

    Corresponding author
    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    • Correspondence address:

      Dr. A. Lejeune

      University of California, Davis

      William R. Pritchard Veterinary Medical Teaching Hospital

      One Garrod Drive

      Davis, CA 95616, USA

      e-mail: alejeune@ucdavis.edu

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  • K. Skorupski,

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA
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  • S. Frazier,

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA
    3. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA
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  • I. Vanhaezebrouck,

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, USA
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  • R. B. Rebhun,

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA
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  • C. M. Reilly,

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Veterinary Pathology, Microbiology and Immunology, University of California, Davis, CA, USA
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  • C. O. Rodriguez Jr.

    1. Davis William R. Pritchard Veterinary Medical Teaching Hospital, University of California, Davis, CA, USA
    2. Department of Veterinary Surgical and Radiological Sciences, University of California, Davis, CA, USA
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  • Presented in abstract form at the Veterinary Cancer Society Annual Conference, Albuquerque, New Mexico, November 2011.

Abstract

This retrospective case series evaluates the outcome of 21 dogs with grade II stage 2 mast cell tumour (MCT) treated with adequate local therapy and adjuvant systemic chemotherapy (prednisone, vinblastine and CCNU). The median survival for all dogs was 1359 days (range, 188–2340). Median disease-free interval was 2120 days (149–2325 days). Dogs treated with surgery and chemotherapy had shorter survival (median, 1103 days; 188–2010 days) than those that underwent surgery, radiation therapy and chemotherapy as part of their treatment (median, 2056 days; 300–2340 days). Two patients had local recurrence in the radiation field and four patients had de novo MCT. Distant metastasis was not observed in any dogs. The results of this study suggest that, in the presence of loco-regional lymph node metastasis in grade II MCT, the use of prednisone, vinblastine and CCNU after adequate local-regional therapy can provide a median survival in excess of 40 months.

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