Prognostic value of baseline absolute lymphocyte concentration and neutrophil/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma

Authors

  • M. Mutz,

    Corresponding author
    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
    • Correspondence address:

      M. Mutz

      Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine

      Louisiana State University

      Skip Bertman Drive

      Baton Rouge, LA 70803, USA

      e-mail: mmutz@vetmed.lsu.edu

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  • B. Boudreaux,

    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
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  • M. Kearney,

    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
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  • K. Stroda,

    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
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  • S. Gaunt,

    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
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  • K. Shiomitsu

    1. Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
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Abstract

Canine multi-centric B-cell lymphoma shares similarities with diffuse large B-cell (Non-Hodgkin's) lymphoma (NHL) in people. In people with NHL, lymphopenia at diagnosis and first relapse and neutrophil/lymphocyte ratio (N:L) > 3.5 are negative prognostic factors for survival. The objective of this study was to determine if lymphocyte concentration at diagnosis and first relapse and N:L were prognostic for survival in dogs with newly diagnosed multi-centric lymphoma. Medical records of 77 dogs with multi-centric lymphoma treated with a CHOP-based chemotherapy protocol were retrospectively evaluated. Absolute lymphocyte concentration and N:L ratio at presentation of dogs pre-treated with steroids was not significantly different from dogs who had not received steroids. On multivariate analysis, only immunophenotype remained significant for progression-free survival (PFS), whereas no variables remained significant for ST. A prospective study of these haematologic variables is warranted to assess their true significance.

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