Present address: Nashville Veterinary Specialists and Animal Emergency, Nashville, TN, USA.
Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs†
Article first published online: 6 SEP 2013
© 2013 John Wiley & Sons Ltd
Veterinary and Comparative Oncology
How to Cite
Mariani, C. L., Schubert, T. A., House, R. A., Wong, M. A., Hopkins, A. L., Barnes Heller, H. L., Milner, R. J., Lester, N. V., Lurie, D. M., Rajon, D. A., Friedman, W. A. and Bova, F. J. (2013), Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs. Veterinary and Comparative Oncology. doi: 10.1111/vco.12056
Parts of this work were presented in abstract form at the 23rd and 24th annual American College of Veterinary Internal Medicine Forums in Baltimore, MD, USA and Louisville, KY, USA. This study was completed at the University of Florida Veterinary Medical Center and the Evelyn F. & William L. McKnight Brain Institute at the University of Florida, Gainesville, FL, USA.
- Article first published online: 6 SEP 2013
- Manuscript Accepted: 24 JUN 2013
- Manuscript Revised: 1 JUN 2013
- Manuscript Received: 6 NOV 2012
- University of Florida Research Opportunity Seed Fund Grant
- brain tumour;
- radiation oncology;
- small animal
Stereotactic radiosurgery (SRS) is a procedure that delivers a single large radiation dose to a well-defined target. Here, we describe a frameless SRS technique suitable for intracranial targets in canines. Medical records of dogs diagnosed with a primary intracranial tumour by imaging or histopathology that underwent SRS were retrospectively reviewed. Frameless SRS was used successfully to treat tumours in 51 dogs with a variety of head sizes and shapes. Tumours diagnosed included 38 meningiomas, 4 pituitary tumours, 4 trigeminal nerve tumours, 3 gliomas, 1 histiocytic sarcoma and 1 choroid plexus tumour. Median survival time was 399 days for all tumours and for dogs with meningiomas; cause-specific survival was 493 days for both cohorts. Acute grade III central nervous system toxicity (altered mentation) occurred in two dogs. Frameless SRS resulted in survival times comparable to conventional radiation therapy, but with fewer acute adverse effects and only a single anaesthetic episode required for therapy.