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Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs

Authors

  • C. L. Mariani,

    Corresponding author
    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
    • Correspondence address:

      C. L. Mariani

      Department of Clinical Sciences

      College of Veterinary Medicine

      North Carolina State University

      1060 William Moore Drive

      Raleigh, NC 27607, USA

      e-mail: chris_mariani@ncsu.edu

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  • T. A. Schubert,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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  • R. A. House,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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    • Present address: Nashville Veterinary Specialists and Animal Emergency, Nashville, TN, USA.
  • M. A. Wong,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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    • Present address: Southeast Veterinary Neurology, Miami, FL, USA.
  • A. L. Hopkins,

    1. North Florida Neurology, Orange Park, FL, USA
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  • H. L. Barnes Heller,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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    • Present address: Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
  • R. J. Milner,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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  • N. V. Lester,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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    • Present address: Perth Veterinary Specialists, Osborne Park, Western Australia, Australia.
  • D. M. Lurie,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA
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    • Present address: Affiliated Veterinary Specialists, Maitland, FL, USA.
  • D. A. Rajon,

    1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA
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  • W. A. Friedman,

    1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA
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  • F. J. Bova

    1. Department of Neurosurgery, College of Medicine, University of Florida, Gainesville, FL, USA
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  • Parts of this work were presented in abstract form at the 23rd and 24th annual American College of Veterinary Internal Medicine Forums in Baltimore, MD, USA and Louisville, KY, USA. This study was completed at the University of Florida Veterinary Medical Center and the Evelyn F. & William L. McKnight Brain Institute at the University of Florida, Gainesville, FL, USA.

Abstract

Stereotactic radiosurgery (SRS) is a procedure that delivers a single large radiation dose to a well-defined target. Here, we describe a frameless SRS technique suitable for intracranial targets in canines. Medical records of dogs diagnosed with a primary intracranial tumour by imaging or histopathology that underwent SRS were retrospectively reviewed. Frameless SRS was used successfully to treat tumours in 51 dogs with a variety of head sizes and shapes. Tumours diagnosed included 38 meningiomas, 4 pituitary tumours, 4 trigeminal nerve tumours, 3 gliomas, 1 histiocytic sarcoma and 1 choroid plexus tumour. Median survival time was 399 days for all tumours and for dogs with meningiomas; cause-specific survival was 493 days for both cohorts. Acute grade III central nervous system toxicity (altered mentation) occurred in two dogs. Frameless SRS resulted in survival times comparable to conventional radiation therapy, but with fewer acute adverse effects and only a single anaesthetic episode required for therapy.

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