Present address: San Mateo Emergency Pet Care and Veterinary Specialists, San Mateo, CA, USA
A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes‡
Version of Record online: 19 JUN 2014
© 2014 John Wiley & Sons Ltd
Veterinary and Comparative Oncology
How to Cite
Bentley, R. T., Burcham, G. N., Heng, H. G., Levine, J. M., Longshore, R., Carrera-Justiz, S., Cameron, S., Kopf, K. and Miller, M. A. (2014), A comparison of clinical, magnetic resonance imaging and pathological findings in dogs with gliomatosis cerebri, focusing on cases with minimal magnetic resonance imaging changes‡. Veterinary and Comparative Oncology. doi: 10.1111/vco.12106
Part of this study was presented in abstract form at the Second Bi-Annual Veterinary Neurosurgical Society Symposium, Portland, OR, USA, August 2013.
- Version of Record online: 19 JUN 2014
- Manuscript Revised: 28 MAY 2014
- Manuscript Accepted: 28 MAY 2014
- Manuscript Received: 26 FEB 2014
The primary study objective was to determine whether clinical examination and magnetic resonance imaging (MRI) can underestimate canine gliomatosis cerebri (GC); we also investigated immunohistochemical features. Seven dogs with GC were studied; four recruited specifically because of minimal MRI changes. Neuroanatomic localization and the distribution of MRI, gross and sub-gross lesions were compared with the actual histological distribution of neoplastic cells. In six cases, clinical examination predicted focal disease and MRI demonstrated a single lesion or appeared normal. Neoplastic cells infiltrated many regions deemed normal by clinical examination and MRI, and were Olig2-positive and glial fibrillary acid protein-negative. Four dogs had concurrent gliomas. GC is a differential diagnosis for dogs with focal neurological deficits and a normal MRI or a focal MRI lesion. Canine GC is probably mainly oligodendrocytic. Type II GC, a solid glioma accompanying diffuse central nervous system neoplastic infiltration, occurs in dogs as in people.