Clinicopathologic and electrocardiographic features of Akita dogs with high and low erythrocyte potassium phenotypes
Article first published online: 9 JAN 2014
© 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology
Veterinary Clinical Pathology
Volume 43, Issue 1, pages 50–54, March 2014
How to Cite
Conrado, F. O., Oliveira, S. T., Lacerda, L. A., Silva, M. O. D., Hlavac, N. and González, F. H. D. (2014), Clinicopathologic and electrocardiographic features of Akita dogs with high and low erythrocyte potassium phenotypes. Veterinary Clinical Pathology, 43: 50–54. doi: 10.1111/vcp.12112
- Issue published online: 3 MAR 2014
- Article first published online: 9 JAN 2014
- Waltham Foundation
- Japanese dog breeds;
- Na-K pump;
- red blood cell
Canine RBCs are expected to have high sodium and low potassium (LK) concentrations. However, some dogs have a low sodium and high potassium (HK) phenotype due to a Na-K pump in the mature RBC membrane. Awareness of this particularity avoids misinterpretation of hyperkalemia in affected dogs.
The purpose of this study was to compare the CBCs, serum biochemistry profiles, urinalysis data, and electrocardiography data in HK and LK Akita dogs.
In this study, the intra-RBC potassium (KRBC) was measured in 48 healthy adult Akita dogs. The HK group included dogs with KRBC concentration at least 5-fold that of plasma, while the LK dogs served as controls.
The HK phenotype was determined in 10 dogs (21%). With the exception of higher plasma potassium concentrations in the HK group compared with LK controls (6.6 mmol/L vs 4.4 mmol/L, P < .001), there were no other differences in serum biochemistry variables. In hematology, mean HGB concentration (13.5 vs 15.9, P < .001), PCV (42.9 vs 46.7, P = .009), RBC (6.1 vs 7.4, P < .001), and MCHC (31.3 vs 34.0, P < .001) were significantly lower in the HK group, while MCV (70.0 vs 63.4, P < .001) was higher compared with the LK controls. There were no significant differences in urinalysis or electrocardiography data between groups.
HK Akita dogs showed significant differences in several hematologic variables, as well as higher plasma potassium concentration. Therefore, the HK phenotype should be considered in the interpretation of these variables in this breed.