Dr. Radin, an editor of the journal, was not involved in the peer-review process or the decision to publish this article.
Platelet vacuoles in a dog with severe nonregenerative anemia: evidence of platelet autophagy
Article first published online: 27 JUN 2014
© 2014 American Society for Veterinary Clinical Pathology and European Society for Veterinary Clinical Pathology
Veterinary Clinical Pathology
Volume 43, Issue 3, pages 326–329, September 2014
How to Cite
Pieczarka, E. M., Yamaguchi, M., Wellman, M. L. and Judith Radin, M. (2014), Platelet vacuoles in a dog with severe nonregenerative anemia: evidence of platelet autophagy. Veterinary Clinical Pathology, 43: 326–329. doi: 10.1111/vcp.12170
- Issue published online: 3 SEP 2014
- Article first published online: 27 JUN 2014
- transmission electron microscopy;
A 13-year-old neutered male English Springer Spaniel was presented to The Ohio State University Veterinary Medical Center for evaluation of severe anemia. Upon blood smear review, approximately 50% of the platelets contained single to multiple variably sized clear vacuoles. Transmission electron microscopy of the platelets revealed hallmark features of autophagy, including membrane-lined vesicles and vacuoles containing membrane whorls and degrading organelles. While autophagy has been demonstrated in a wide range of eukaryotic cells for decades, reports of platelet autophagy are lacking. This case report illustrates atypical platelet vacuolation with electron microscopic features characteristic of autophagy.