Source of Funding: This study was self-funded.
Pemphigus vulgaris in a Welsh pony stallion: case report and demonstration of antidesmoglein autoantibodies
Article first published online: 25 JAN 2013
© 2013 The Authors. Veterinary Dermatology © 2013 ESVD and ACVD
Volume 24, Issue 2, pages 269–e60, April 2013
How to Cite
Winfield, L. D., White, S. D., Affolter, V. K., Renier, A. C., Dawson, D., Olivry, T., Outerbridge, C. A., Wang, Y. H., Iyori, K. and Nishifuji, K. (2013), Pemphigus vulgaris in a Welsh pony stallion: case report and demonstration of antidesmoglein autoantibodies. Veterinary Dermatology, 24: 269–e60. doi: 10.1111/vde.12002
Conflict of Interest: No conflicts of interest have been declared.
- Issue published online: 7 MAR 2013
- Article first published online: 25 JAN 2013
- Manuscript Accepted: 11 OCT 2012
|vde12002-sup-0001-FigS1.tif||image/tif||9712K||Figure S1. Welsh pony with pemphigus vulgaris (PV).|
|vde12002-sup-0002-FigS2.tif||image/tif||3547K||Figure S2. Welsh pony with PV: oral ulcers.|
|vde12002-sup-0003-FigS3.tif||image/tif||1625K||Figure S3. Indirect immunofluorescence showing the presence of circulating antikeratinocyte IgG autoantibodies (equine lip substrate) in a ‘bottom heavy’ pattern (bright green fluorescence – white arrow) compatible with an anti-desmoglein (Dsg)-3 response.|
|vde12002-sup-0004-FigS4.tif||image/tif||18116K||Figure S4. Welsh pony with PV, 2 weeks after initiating systemic corticosteroid treatment.|
|vde12002-sup-0005-FigS5.tif||image/tif||7363K||Figure S5. Welsh pony with PV, 6 weeks after tapering and finally discontinuing prednisolone dosage due to laminitis.|
|vde12002-sup-0006-FigS6.tif||image/tif||15394K||Figure S6. Welsh pony with PV: muzzle at necropsy.|
|vde12002-sup-0007-FigS7.tif||image/tif||4053K||Figure S7. Photomicrograph of skin taken at necropsy. Marked suprabasilar clefting and vesicle formation containing serum and hemorrhage and a few free floating acantholytic keratinocytes (arrow pointing up). The base of the vesicle is lined by basal cells (‘tombstones’; arrow pointing down). H & E, bar: 200 mm.|
|vde12002-sup-0008-FigS8.tif||image/tif||9408K||Figure S8. Pemphigus vulgaris serum diluted to 1:50 was preincubated with either control supernatants (C) or cDsg3 (D), and then subjected to indirect immunofluorescence using equine buccal mucosa as substrate. The reactivity of IgG against equine keratinocytes (C) was absorbed by cDsg3 (D) (absence of fluorescence). Bar = 100 μm.|
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