Philippa A. Ravens, Linda J. Vogelnest, Lydia J. Tong, Lauren E. Demos and Mark D. Bennett
Background – Multicentric squamous cell carcinoma in situ (MSCCIS) is an uncommon cutaneous disease of middle-aged to older cats, with some cases being linked to papillomavirus infection. The disease course is usually benign. Initial eruption of multifocal, pigmented, hyperkeratotic plaques is typical, with gradual progression to thickly crusted ulcerative lesions. Conclusions – This case represents an unusual presentation of papillomavirus-associated MSCCIS with extensive lesions, atypical initial histopathology and progression to SCC with distant metastases.