Presumptive central nervous system cuterebriasis and concurrent protein-losing nephropathy in a dog


  • Presented in part at the 17th International Veterinary Emergency and Critical Care Symposium, Nashville, Tennessee, September 2011.

  • The authors declare no conflict of interests.

Address correspondence and reprint requests to Dr. Vincent Thawley, Matthew J. Ryan Veterinary Hospital, University of Pennsylvania, 3900 Delancey St, Philadelphia, PA 19104, USA.




To describe the clinical course and successful management of a dog suspected to have central nervous system (CNS) Cuterebra larval migration and concurrent protein-losing nephropathy (PLN).

Case Summary

A 1-year-old castrated male mixed breed dog was diagnosed with presumptive CNS cuterebriasis based on history, progressively deteriorating mentation, seizures, and magnetic resonance images showing a tubular lesion consistent with a migrating Cuterebra tract. Additionally, serum biochemistry and urine analyses revealed the development of a severe PLN. Surgical removal of the Cuterebra was attempted unsuccessfully, and subsequently, the dog was treated with ivermectin, antihistamines, anticonvulsants, and a tapering dose of glucocorticoids. Over several weeks the dog's neurologic status improved and the PLN resolved completely.

New or Unique Information Provided

This case describes successful management of presumptive CNS cuterebriasis in a dog. It is also, to our knowledge, the first report of PLN associated with cuterebriasis in the veterinary literature.