The author declares no conflict of interest.
State of the Art Review
Renal pathophysiology: lessons learned from the canine remnant kidney model
Article first published online: 6 MAR 2013
© Veterinary Emergency and Critical Care Society 2013
Journal of Veterinary Emergency and Critical Care
Special Issue: Advances in Renal Physiology and Therapy
Volume 23, Issue 2, pages 115–121, March/April 2013
How to Cite
Brown, S. A. (2013), Renal pathophysiology: lessons learned from the canine remnant kidney model. Journal of Veterinary Emergency and Critical Care, 23: 115–121. doi: 10.1111/vec.12030
- Issue published online: 8 APR 2013
- Article first published online: 6 MAR 2013
- Manuscript Accepted: 2 FEB 2013
- Manuscript Received: 12 JUN 2012
- chronic kidney disease;
To review the pathophysiology of chronic kidney disease (CKD) in dogs and the contributions of the canine remnant kidney model to our understanding of this disease.
Original studies in the human and veterinary medical fields.
Three of the fundamental principles of modern nephrology—the intact nephron hypothesis, the trade-off hypothesis, and the hyperfiltration theory were developed directly as a result of studies of the remnant kidney model. Most of the pivotal early studies were conducted in dogs. As a result, our understanding of CKD, and of the renal and systemic adaptations to CKD, is largely based on studies of this model.
Studies of the remnant kidney model have advanced our understanding of the pathophysiology of CKD. Nearly every therapeutic intervention used in CKD, by veterinarians and physicians alike, has its basis in studies of the remnant kidney model or in knowledge that was derived from studies of this model. A great debt is owed to the canine participants in these studies and to a small number of key scientists who conducted this important and insightful research.