The authors declare no conflict of interests.
Intramuscular glargine with or without concurrent subcutaneous administration for treatment of feline diabetic ketoacidosis
Article first published online: 26 MAR 2013
© Veterinary Emergency and Critical Care Society 2013
Journal of Veterinary Emergency and Critical Care
Volume 23, Issue 3, pages 286–290, May/June 2013
How to Cite
Marshall, R. D., Rand, J. S., Gunew, M. N. and Menrath, V. H. (2013), Intramuscular glargine with or without concurrent subcutaneous administration for treatment of feline diabetic ketoacidosis. Journal of Veterinary Emergency and Critical Care, 23: 286–290. doi: 10.1111/vec.12038
- Issue published online: 4 JUN 2013
- Article first published online: 26 MAR 2013
- Manuscript Accepted: 12 FEB 2013
- Manuscript Received: 5 JAN 2012
To describe treatment response and outcome in 15 cats with diabetic ketoacidosis (DKA) initially stabilized with glargine administered intramuscularly (IM) with or without subcutaneous (SC) glargine.
Materials and Methods
Fifteen cats diagnosed with DKA were initially administered IM glargine (1–2 U) and in most cats (12/15 cats) this was combined with SC glargine (1–3 U). This was followed by intermittent IM glargine as required at intervals of 2 or more hours (range 2–22 h) and SC glargine (1–2 U) every 12 hours.
All 15 cats survived and were discharged from hospital (median 4 d; range 2–5 d) and one-third (5/15) of cats subsequently achieved remission (median time 20 d; range 15–29 d). Complications included hypokalemia and hypophosphatemia, which were likely the result of DKA therapy rather than glargine treatment specifically.
This study demonstrates that glargine administered IM is an effective treatment for DKA in cats, and may provide an alternative to regular insulin. The same vial used for initial treatment of DKA can then be used for subsequent management with SC glargine injections. Future prospective randomized controlled trials evaluating clinical outcomes in cats with DKA using different types and routes of administration of insulin are warranted. A prospective randomized controlled trial is required to compare outcomes for IM and IV administration of glargine and regular insulin in DKA cats with or without SC glargine.