The authors declare no conflict of interest.
Brief Clinical Communication
Intravenous administration of desmopressin acetate to reverse acetylsalicylic acid-induced coagulopathy in three dogs
Version of Record online: 15 JUL 2013
© Veterinary Emergency and Critical Care Society 2013
Journal of Veterinary Emergency and Critical Care
Volume 23, Issue 4, pages 455–458, July/August 2013
How to Cite
Di Mauro, F. M. and Holowaychuk, M. K. (2013), Intravenous administration of desmopressin acetate to reverse acetylsalicylic acid-induced coagulopathy in three dogs. Journal of Veterinary Emergency and Critical Care, 23: 455–458. doi: 10.1111/vec.12067
- Issue online: 5 AUG 2013
- Version of Record online: 15 JUL 2013
- Manuscript Accepted: 28 MAY 2013
- Manuscript Received: 25 JAN 2012
- antithrombotic reversal;
- platelet dysfunction
Acetylsalicylic acid (ie, aspirin) administration inhibits platelet aggregation in dogs and is associated with increased perioperative blood loss and transfusion requirements in people. Desmopressin acetate (DDAVP) is used to control or prevent bleeding in dogs with type 1 von Willebrand disease and is also widely reported in the human literature as an emergency antithrombotic reversal agent.
Three dogs undergoing surgery for intervertebral disc disease had marked prolongations in buccal mucosal bleeding time (BMBT) after aspirin administration. DDAVP was given intravenously preoperatively and achieved prompt reversal of the prolongation in BMBT. None of the dogs experienced intraoperative bleeding complications.
IV DDAVP corrected prolongations in BMBT in dogs given aspirin and should be considered in dogs requiring prompt reversal of aspirin-induced coagulopathies to reduce the risk of bleeding complications.