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Partnership on Rotational ViscoElastic Test Standardization (PROVETS): Evidence-based guidelines on rotational viscoelastic assays in veterinary medicine

Authors

  • Robert Goggs BVSc, DACVECC, PhD, MRCVS,

    Corresponding author
    1. From the Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY
    • Address correspondence and reprint requests toDr. Robert Goggs, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.Email: r.goggs@cornell.edu

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  • Benjamin Brainard VMD, DACVA, DACVECC,

    1. Department of Small Animal Medicine & Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602
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    • These authors contributed equally to this work.

  • Armelle M. de Laforcade DVM, DACVECC,

    1. Department of Clinical Sciences, Tufts Cummings School of Veterinary Medicine, North Grafton, MA 01536
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    • These authors contributed equally to this work.

  • Bente Flatland DVM, MS, DACVIM, DACVP,

    1. Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996
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    • These authors contributed equally to this work.

  • Rita Hanel DVM, DACVIM, DACVECC,

    1. Department of Clinical Sciences, College of Veterinary Medicine, NC State University, Raleigh, NC 27607
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    • These authors contributed equally to this work.

  • Maureen McMichael DVM, DACVECC,

    1. Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana, IL 61801
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    • These authors contributed equally to this work.

  • Bo Wiinberg DVM, PhD

    1. Novo Nordisk, Malov, Denmark
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  • The authors declare no conflicts of interests.

Abstract

Objective

To systematically examine the evidence relating to the performance of rotational viscoelastic testing in companion animals, to develop assay guidelines, and to identify knowledge gaps.

Design

Multiple questions were considered within 5 parent domains, specifically system comparability, sample handling, assay activation and test protocol, definitions and data reporting, and nonstandard assays. Standardized, systematic evaluation of the literature was performed. Relevant articles were categorized according to level of evidence and assessed for quality. Consensus was developed regarding conclusions for application of concepts to clinical practice.

Setting

Academic and referral veterinary medical centers.

Results

Databases searched included Medline, Commonwealth Agricultural Bureaux abstracts, and Google Scholar. Worksheets were prepared evaluating 28 questions across the 5 domains and generating 84 assay guidelines.

Conclusions

Evidence-based guidelines for the performance of thromboelastography in companion animals were generated through this process. Some of these guidelines are well supported while others will benefit from additional evidence. Many knowledge gaps were identified and future work should be directed to address these gaps and to objectively evaluate the impact of these guidelines on assay comparability within and between centers.

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