*These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.
Systematic evaluation of evidence on veterinary viscoelastic testing Part 4: Definitions and data reporting
Article first published online: 28 JAN 2014
© Veterinary Emergency and Critical Care Society 2014
Journal of Veterinary Emergency and Critical Care
Volume 24, Issue 1, pages 47–56, January/February 2014
How to Cite
Hanel, R. M., Chan, D. L., Conner, B., Gauthier, V., Holowaychuk, M., Istvan, S., Walker, J. M., Wood, D., Goggs, R. and Wiinberg, B. (2014), Systematic evaluation of evidence on veterinary viscoelastic testing Part 4: Definitions and data reporting. Journal of Veterinary Emergency and Critical Care, 24: 47–56. doi: 10.1111/vec.12145
Offprints will not be available from the authors.
- Issue published online: 28 JAN 2014
- Article first published online: 28 JAN 2014
- Manuscript Accepted: 15 NOV 2013
- Manuscript Received: 13 NOV 2013
To systematically examine evidence surrounding definitions and reporting of data for viscoelastic testing in veterinary medicine.
Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice.
Academic and referral veterinary medical centers.
Databases searched included Medline, CAB abstracts, and Google Scholar.
All 4 standard thromboelastography (TEG) and rotational thromboelastometry (ROTEM) variables should be universally reported, and the reporting of shear elastic modulus in addition to maximum amplitude (MA) is encouraged. There is insufficient evidence to support universal usage of the coagulation index at this time. The K value and clot formation time are the most variable of the 4 parameters, with alpha angle, MA, and maximum clot firmness generally the least variable. Individual studies should report sufficient data on patients and institutional controls to enable definitions of hypo- and hypercoagulability to be evaluated post-hoc, and it is recommended that all studies specifically report how these conditions were defined. In reporting data relating to fibrinolysis, the TEG variables LY30, LY60, CL30, CL60, and the ROTEM variables LI30, LI60, ML, LOT, and LT should be documented. Studies should report sufficient data on patients and controls to enable definitions of hyper- and hypofibrinolysis to be evaluated post-hoc, and we suggest that standard TEG/ROTEM assays may be unable to detect hypofibrinolysis in companion animals. We recommend that every center establish reference intervals, which are specific to either TEG or ROTEM. These reference intervals should be established using veterinary clinical pathology guidelines, standardized protocols, and a minimum of 40 healthy animals. There are currently insufficient data in companion animals to suggest a utility for Vcurve variables beyond that of standard TEG variables.