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Systematic evaluation of evidence on veterinary viscoelastic testing Part 4: Definitions and data reporting

Authors

  • Rita M. Hanel DVM, DACVIM, DACVECC,

    Corresponding author
    1. From the Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27607
    • Address correspondence to Rita Hanel, DoCS, NCSU CVM, 1052 William Moore Drive, Raleigh, NC 27607. E-mail: Rita_Hanel@ncsu.edu

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  • Daniel L. Chan DVM, DACVECC, DACVN, MRCVS,

    1. Clinical Science and Services, The Royal Veterinary College, University to London, North Mymms, Hertfordshire, UK AL9 7TA
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Bobbi Conner DVM, DACVECC,

    1. Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32608
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Vincent Gauthier DVM, DVSc, DACVECC,

    1. Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1L 1G6
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Marie Holowaychuk DVM, DACVECC,

    1. Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1L 1G6
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Stephanie Istvan VMD, DACVECC,

    1. Emergency Animal Clinic, Phoenix, AZ 85021
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Julie M. Walker DVM, DACVECC,

    1. Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Darren Wood DVM, DVSc, DACVP,

    1. Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1L 1G6
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    • *These authors, listed alphabetically, contributed equally to this manuscript. Five of the authors (Hanel, Chan, Walker, Goggs, Wiinberg) are coauthors in one or more publications that met inclusion criteria for this domain. The authors declare no conflict of interests.

  • Robert Goggs BVSc, DACVECC, MRCVS,

    1. Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853
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  • Bo Wiinberg DVM, PhD

    1. and Novo Nordisk, Malov, Denmark
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  • Offprints will not be available from the authors.

Abstract

Objective

To systematically examine evidence surrounding definitions and reporting of data for viscoelastic testing in veterinary medicine.

Design

Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice.

Setting

Academic and referral veterinary medical centers.

Results

Databases searched included Medline, CAB abstracts, and Google Scholar.

Conclusions

All 4 standard thromboelastography (TEG) and rotational thromboelastometry (ROTEM) variables should be universally reported, and the reporting of shear elastic modulus in addition to maximum amplitude (MA) is encouraged. There is insufficient evidence to support universal usage of the coagulation index at this time. The K value and clot formation time are the most variable of the 4 parameters, with alpha angle, MA, and maximum clot firmness generally the least variable. Individual studies should report sufficient data on patients and institutional controls to enable definitions of hypo- and hypercoagulability to be evaluated post-hoc, and it is recommended that all studies specifically report how these conditions were defined. In reporting data relating to fibrinolysis, the TEG variables LY30, LY60, CL30, CL60, and the ROTEM variables LI30, LI60, ML, LOT, and LT should be documented. Studies should report sufficient data on patients and controls to enable definitions of hyper- and hypofibrinolysis to be evaluated post-hoc, and we suggest that standard TEG/ROTEM assays may be unable to detect hypofibrinolysis in companion animals. We recommend that every center establish reference intervals, which are specific to either TEG or ROTEM. These reference intervals should be established using veterinary clinical pathology guidelines, standardized protocols, and a minimum of 40 healthy animals. There are currently insufficient data in companion animals to suggest a utility for Vcurve variables beyond that of standard TEG variables.

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