The authors declare no conflicts of interests.
Systematic evaluation of evidence on veterinary viscoelastic testing Part 5: Nonstandard assays
Article first published online: 10 JAN 2014
© Veterinary Emergency and Critical Care Society 2014
Journal of Veterinary Emergency and Critical Care
Volume 24, Issue 1, pages 57–62, January/February 2014
How to Cite
Brainard, B. M., Goggs, R., Mendez-Angulo, J. L., Mudge, M. C., Ralph, A. G. and Wiinberg, B. (2014), Systematic evaluation of evidence on veterinary viscoelastic testing Part 5: Nonstandard assays. Journal of Veterinary Emergency and Critical Care, 24: 57–62. doi: 10.1111/vec.12146
- Issue published online: 28 JAN 2014
- Article first published online: 10 JAN 2014
- Manuscript Accepted: 15 NOV 2013
- Manuscript Received: 8 NOV 2013
To systematically examine the evidence on nontraditional uses of viscoelastic coagulation monitoring in veterinary species.
Standardized, systematic evaluation of the literature, categorization of relevant articles according to level of evidence and quality, and development of consensus on conclusions for application of the concepts to clinical practice.
Academic and referral veterinary medical centers.
Databases searched included Medline, CAB abstracts, and Google Scholar.
Nontraditional assays identified included thrombelastography (TEG)-PlateletMapping (PM), functional fibrinogen assessment, and rapid-TEG (r-TEG). Direct veterinary evidence was found for only the ADP-activated PM, which appears to generate valid data in dogs but not cats or horses. Arachidonic acid activated PM shows high variability and requires further assessment and validation in veterinary species. Functional fibrinogen assays may be performed in veterinary species but may require modification due to species differences in response to abciximab. While tissue factor (TF)-activated TEG has been well described in the veterinary literature, the specific r-TEG assay has not been assessed, but presumably would be effective for generating TEG tracings and values for maximum amplitude and angle in shorter periods of time than some traditional assays.