The authors declare no conflict of interest.
Evaluation of serum thyroid hormones in dogs with systemic inflammatory response syndrome or sepsis
Article first published online: 3 APR 2014
© Veterinary Emergency and Critical Care Society 2014
Journal of Veterinary Emergency and Critical Care
Volume 24, Issue 3, pages 264–271, May/June 2014
How to Cite
Pashmakova, M. B., Bishop, M. A., Steiner, J. M., Suchodolski, J. S. and Barr, J. W. (2014), Evaluation of serum thyroid hormones in dogs with systemic inflammatory response syndrome or sepsis. Journal of Veterinary Emergency and Critical Care, 24: 264–271. doi: 10.1111/vec.12172
A portion of this study was funded by Abbott Laboratories as part of a larger study on biochemical derangements in septic dogs.
- Issue published online: 24 JUN 2014
- Article first published online: 3 APR 2014
- Manuscript Accepted: 11 JAN 2014
- Manuscript Received: 18 JUN 2012
- Abbott Laboratories as part of a larger study on biochemical derangements in septic dogs
- APPLE score;
- critical illness;
- endocrine function;
- illness severity;
To determine whether dogs with systemic inflammatory response syndrome (SIRS) or sepsis have derangements in serum thyroid hormone concentrations and to evaluate whether such derangements relate to illness severity or outcome.
Prospective observational study. Dogs hospitalized with SIRS or sepsis between May and December 2010 were included. Serum thyroid hormone concentrations were measured in all dogs. Data obtained on admission were used to calculate the Acute Patient Physiologic and Laboratory Evaluation (APPLE) scores.
University teaching hospital.
Twenty-two consecutive client-owned dogs hospitalized with SIRS or sepsis were enrolled; 18 dogs completed the study and 4 dogs were excluded for incomplete data. Forty-nine healthy dogs owned by volunteers were used as controls.
Measurements and Main Results
Decreased total thyroxine (TT4) concentrations were documented in all septic and 7/9 dogs with SIRS. Free T4 concentrations were decreased, but were within the reference interval in 12/18 dogs with SIRS or sepsis compared to control dogs (P < 0.001). Dogs with increased APPLE(fast) scores were less likely to survive (P = 0.017).
Dogs with SIRS or sepsis have derangements in measured serum thyroid hormones. No relationships were identified between thyroid hormone concentrations and survival. The APPLE(fast) score was the only variable predictive of poor outcome.