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Keywords:

  • APPLE score;
  • critical illness;
  • endocrine function;
  • illness severity;
  • SIRS

Abstract

Objective

To determine whether dogs with systemic inflammatory response syndrome (SIRS) or sepsis have derangements in serum thyroid hormone concentrations and to evaluate whether such derangements relate to illness severity or outcome.

Design

Prospective observational study. Dogs hospitalized with SIRS or sepsis between May and December 2010 were included. Serum thyroid hormone concentrations were measured in all dogs. Data obtained on admission were used to calculate the Acute Patient Physiologic and Laboratory Evaluation (APPLE) scores.

Setting

University teaching hospital.

Animals

Twenty-two consecutive client-owned dogs hospitalized with SIRS or sepsis were enrolled; 18 dogs completed the study and 4 dogs were excluded for incomplete data. Forty-nine healthy dogs owned by volunteers were used as controls.

Interventions

None.

Measurements and Main Results

Decreased total thyroxine (TT4) concentrations were documented in all septic and 7/9 dogs with SIRS. Free T4 concentrations were decreased, but were within the reference interval in 12/18 dogs with SIRS or sepsis compared to control dogs (P < 0.001). Dogs with increased APPLE(fast) scores were less likely to survive (P = 0.017).

Conclusions

Dogs with SIRS or sepsis have derangements in measured serum thyroid hormones. No relationships were identified between thyroid hormone concentrations and survival. The APPLE(fast) score was the only variable predictive of poor outcome.