Original Research-Basic Science
A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds
Article first published online: 22 APR 2013
© 2013 by the Wound Healing Society
Wound Repair and Regeneration
Volume 21, Issue 3, pages 473–481, May-June 2013
How to Cite
Elgharably, H., Roy, S., Khanna, S., Abas, M., DasGhatak, P., Das, A., Mohammed, K. and Sen, C. K. (2013), A modified collagen gel enhances healing outcome in a preclinical swine model of excisional wounds. Wound Repair and Regeneration, 21: 473–481. doi: 10.1111/wrr.12039
- Issue published online: 3 MAY 2013
- Article first published online: 22 APR 2013
- Manuscript Accepted: 31 JAN 2013
- Manuscript Received: 7 MAR 2012
- Southwest Technologies Inc.
- National Institutes of Health. Grant Number: GM077185, GM069589, DK076566
Figure S1. Representative MS/MS spectrum of peptide 132VVAGVANALAHR 143 from hemoglobin subunit beta (bovine). The scan sequence of the mass spectrometer was based on the TopTen method; the analysis was programmed for a full scan recorded between 350–2000 Da, and a MS/MS scan to generate product ion spectra to determine amino acid sequence in consecutive instrument scans of the ten most abundant peak in the spectrum. Protein identifications were checked manually and proteins with a Mascot score of 50 or higher with a minimum of two unique peptides from one protein having a -b or -y ion sequence tag of five residues or better were accepted.
Figure S2. Experiment design. (A) Four sets with 8 excisional 3 mm punch wounds in each set were created on each side of the back of pigs (n = 4). One set of 8 wounds were collected at specified time points (days 3–21) postwounding. (B) Wounds on one side of the back were either treated with a modified collagen gel (MCG), followed by covering with Tegaderm (TD) or TD alone (control, contralateral side).
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