Chronic venous leg ulcer treatment: Future research needs

Authors

  • Gerald Lazarus MD,

    Corresponding author
    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
    • Reprint requests:

      Dr. G. Lazarus, MD, Department of Dermatology, Johns Hopkins Bayview Medical Center, 4940 Eastern Ave, Baltimore, MD 21224, USA.

      Tel: +410-490-0813;

      Fax: +410-550-7301;

      Email: glazaru1@jhmi.edu

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  • M. Fran Valle DNP, MS,

    1. School of Nursing, University of Maryland, Baltimore, Maryland
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  • Mahmoud Malas MD, MHS,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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  • Umair Qazi MD, MPH,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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  • Nisa M. Maruthur MD, MHS,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
    2. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland
    3. Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University, Baltimore, Maryland
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  • David Doggett PhD,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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  • Oluwakemi A. Fawole MBCHB, MPH,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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  • Eric B. Bass MD, MPH,

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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  • Jonathan Zenilman MD

    1. Departments of Dermatology, Medicine and Surgery, School of Medicine, Johns Hopkins University, Queenstown, Maryland
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Errata

This article is corrected by:

  1. Errata: Erratum Volume 22, Issue 2, 291, Article first published online: 17 March 2014

  • [Correction added after online publication: 06-November-2013: Affiliation 2 has been updated.]

Abstract

The prevalence and costs of chronic venous ulcer care in the US are increasing. The Johns Hopkins University Evidence-Based Practice Center recently completed a systematic review of the comparative effectiveness of advanced wound dressings, antibiotics, and surgical management of chronic venous ulcers. Of 10,066 citations identified in the literature search, only 66 (0.06%) met our liberal inclusion criteria for providing evidence on the effectiveness of interventions for chronic venous ulcers. Based on review of those studies, members of our team and a panel of informed stakeholders identified important research gaps and methodological deficiencies and prioritized specific future research needs. Based on that review, we provide the results of our assessment of future research needs for chronic venous ulcer care. Advanced wound dressings were considered to have the highest priority for future research, followed by venous surgery and antibiotics. An imperative from our assessment is that future research evaluating interventions for chronic venous ulcers meet quality standards. In a time of increasing cost pressure, the wound care community needs to develop high-quality evidence to justify the use of present and future therapeutic modalities.

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