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Two Cases of Cutaneous Diphtheria Associated with Occupational Pig Contact in Germany

Authors

  • A. Berger,

    1. National Consiliary Laboratory for Diphtheria, Oberschleißheim, Germany
    2. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany
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    • Both authors contributed equally to this paper.
  • V. Boschert,

    1. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany
    2. Clinic for Swine, Ludwig-Maximilians-University Munich, Oberschleißheim, Germany
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    • Both authors contributed equally to this paper.
  • R. Konrad,

    1. National Consiliary Laboratory for Diphtheria, Oberschleißheim, Germany
    2. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany
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  • T. Schmidt-Wieland,

    1. Labor Dr. Gaertner, Ravensburg, Germany
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  • S. Hörmansdorfer,

    1. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany
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  • M. Eddicks,

    1. Clinic for Swine, Ludwig-Maximilians-University Munich, Oberschleißheim, Germany
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  • A. Sing

    Corresponding author
    1. National Consiliary Laboratory for Diphtheria, Oberschleißheim, Germany
    2. Bavarian Health and Food Safety Authority, Oberschleißheim, Germany
    • Correspondence:

      Prof. Dr. Andreas Sing. MA DTM&H, Bavarian Health and Food Safety Authority, Veterinärstraße 2, 85764 Oberschleißheim, Germany. Tel. ++49-9131-6808-5814; Fax: ++49-9131-6808-5458; E-mail: andreas.sing@lgl.bayern.de

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Summary

In 2010, two independent cases of cutaneous diphtheria caused by toxigenic C. ulcerans were identified in Germany. Both patients had intense occupational contact with pigs. Diagnostic work-up comprising biochemical differentiation, rpoB sequencing, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) analysis, real-time tox PCR and Elek test as well as public health measures including an intensified source tracing involving 83 asymptomatic pigs of an associated pig farm are presented.

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