Panentheism is an often-discussed alternative to Classical theism, and almost any discussion of panentheism starts by way of acknowledging Karl Christian Friedrich Krause (1781–1832) as the person who coined the term.1 However, apart from this tribute, Krause's own panentheism is almost completely unknown. In what follows, I first present a brief overview of Krause's life and correct some misconceptions of his work before I turn to the core ideas of Krause's own panentheistic system of philosophy. In brief, Krause elaborates a scientific holism that is anchored in intellectual intuition of the Absolute as the one principle of being and recognition. The task of philosophical speculation consequently is twofold: the analytic-ascending part of philosophy proceeds by way of transcendental reflection and according to Krause enables us to obtain intellectual intuition. The synthetic-descending part of philosophy starts by way of showing that science as a whole is an explication of the original union of the Absolute as apprehended in intellectual intuition. Once this is achieved, Krause argues that the emerging philosophy of science is most adequately referred to as “panentheism” since everything is what it is “in and through” the Absolute, while the Absolute itself is not reducible to anything in particular. I end by showing how to relate Krause's panentheism to recent philosophical discussion.