M. Figueiredo and S. Lane contributed equally to this paper.
Optogenetic experimentation on astrocytes
Article first published online: 15 DEC 2010
© 2010 The Authors. Journal compilation © 2010 The Physiological Society
Special Issue: Optogenetics Themed Issue
Volume 96, Issue 1, pages 40–50, January 2011
How to Cite
Figueiredo, M., Lane, S., Tang, F., Liu, B. H., Hewinson, J., Marina, N., Kasymov, V., Souslova, E. A., Chudakov, D. M., Gourine, A. V., Teschemacher, A. G. and Kasparov, S. (2011), Optogenetic experimentation on astrocytes. Experimental Physiology, 96: 40–50. doi: 10.1113/expphysiol.2010.052597
- Issue published online: 15 DEC 2010
- Article first published online: 15 DEC 2010
- (Received 27 September 2010; accepted after revision 28 October 2010; first published online 1 November 2010)
We briefly review the current literature where optogenetics has been used to study various aspects of astrocyte physiology in vitro and in vivo. This includes both genetically engineered Ca2+ sensors and effector proteins, such as channelrhodopsin. We demonstrate how the ability to target astrocytes with cell-specific viral vectors to express optogenetic constructs helped to unravel some previously unsuspected roles of these inconspicuous cells.