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References

  • Adamo ML, Neuenschwander S, LeRoith D & Roberts CTJr (1993). Structure, expression, and regulation of the IGF-I gene. Adv Exp Med Biol 343, 111.
  • Adams GR & McCue SA (1998). Localized infusion of IGF-I results in skeletal muscle hypertrophy in rats. J Appl Physiol 84, 17161722.
  • Andersen NB, Andreassen TT, Orskov H & Oxlund H (2000). Growth hormone and mild exercise in combination increases markedly muscle mass and tetanic tension in old rats. Eur J Endocrinol 143, 409418.
  • Bamman MM, Ship JR, Jiang J, Gower BA, Hunter GR, Goodman A et al. (2001). Mechanical load increases muscle IGF-1 and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinal Metab 280, E383E390.
  • Barton-Davis ER, Shoturma DI, Musaro A, Rosenthal N & Sweeney HL (1998). Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function. Proc Natl Acad Sci U S A 95, 1560315607.
  • Brahm H, Piehl-Aulin K, Saltin B & Ljunghall S (1997). Net fluxes over working thigh of hormones, growth factors and biomarkers of bone metabolism during short lasting dynamic exercise. Calcif Tissue Int 60, 175180.
  • Brill KT, Weltman AL, Gentili A, Patrie JT, Fryburg DA, Hanks JB, Urban RJ & Veldhuis JD (2002). Single and combined effects of growth hormone and testosterone administration on measures of body composition, physical performance, mood, sexual function, bone turnover, and muscle gene expression in healthy older men. J Clin Endocrinol Metab 87, 56495657.
  • Chakravarthy MV, Davis BS & Booth FW (2000). IGF-I restores satellite cell proliferative potential in immobilized old skeletal muscle. J Appl Physiol 89, 13651379.
  • Coleman ME, Demayo F, Yin KC, Lee HM, Geske R, Montgomery C & Schwartz RJ (1995). Myogenic vector expression of insulin-like growth factor I stimulates muscle cell differentiation and myofiber hypertrophy in transgenic mice. J Biol Chem 270, 1210912116.
  • Corpas E, Harman SM & Blackman MR (1993). Human growth hormone and human aging. Endocr Rev 14, 2039.
  • Fiatarone MA, Marks EC, Ryan ND, Meredith CN, Lipsitz LA & Evans WJ (1990). High-intensity strength training in nonagenarians. Effects on skeletal muscle. JAMA 263, 30293034.
  • Fiatarone MA, O'Neill EF, Ryan ND, Clements KM, Solares GR, Nelson ME, Roberts SB, Kehayias JJ, Lipsitz LA & Evans WJ (1994). Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330, 17691775.
  • Goldspink G (2001). Method of treating muscular disorders. United States Patent, US 6, 221,842,B1.
  • Gosteli-Peter MA, Winterhalter KH, Schmid C, Froesch ER & Zapf J (1994). Expression and regulation of insulin-like growth factor-I (IGF-I) and IGF-binding protein messenger ribonucleic acid levels in tissues of hypophysectomized rats infused with IGF-I and growth hormone. Endocrinology 135, 25582567.
  • Haddad F & Adams GR (2002). Selected contribution: acute cellular and molecular responses to resistance exercise. J Appl Physiol 93, 394403.
  • Hameed M, Harridge SD & Goldspink G (2002). Sarcopenia and hypertrophy: a role for insulin-like growth factor-1 in aged muscle Exerc Sport Sci Rev 30, 1519.
  • Hameed M, Orrell RW, Cobbold M, Goldspink G & Harridge SD (2003). Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol 547, 247254.
  • Harridge SD, Kryger A & Stensgaard A (1999). Knee extensor strength, activation, and size in very elderly people following strength training. Muscle Nerve 22, 831839.
  • Hill M & Goldspink G (2003). Expression and splicing of the insulin-like growth factor gene in rodent muscle is associated with muscle satellite (stem) cell activation following local tissue damage. J Physiol 549, 409418.
  • Isaksson OG, Jansson JO & Gause IA (1982). Growth hormone stimulates longitudinal bone growth directly. Science 216, 12371239.
  • Isaksson OG, Lindahl A, Nilsson A & Isgaard J (1987). Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocr Rev 8, 426438.
  • Isgaard J, Nilsson A, Vikman K & Isaksson OG (1989). Growth hormone regulates the level of insulin-like growth factor-I mRNA in rat skeletal muscle. J Endocrinol 120, 107112.
  • Lamberts SW, Van Den Beld AW & Van Der Lely AJ (1997). The endocrinology of aging. Science 278, 419424.
  • Lange KH, Andersen JL, Beyer N, Isaksson F, Larsson B, Rasmussen MH, Juul A, Bulow J & Kjaer M (2002). GH administration changes myosin heavy chain isoforms in skeletal muscle but does not augment muscle strength or hypertrophy, either alone or combined with resistance exercise training in healthy elderly men. J Clin Endocrinol Metab 87, 513523.
  • Lyall J (1996). Transcriptional regulation of the ovine IGF-I gene. PhD Thesis, University of Cambridge .
  • McKoy G, Ashley W, Mander J, Yang SY, Williams N, Russell B & Goldspink G (1999). Expression of insulin growth factor-1 splice variants and structural genes in rabbit skeletal muscle induced by stretch and stimulation. J Physiol 516 (2), 583592.
  • Morley AA (1995). The somatic mutation theory of ageing. Mutat Res 338, 1923.
  • Murphy LJ, Bell GI & Friesen HG (1987). Growth hormone stimulates sequential induction of c-myc and insulin-like growth factor I expression in vivo. Endocrinology 120, 18061812.
  • Musaro A, McCullagh K, Paul A, Houghton L, Dobrowolny G, Molinaro M, Barton ER, Sweeney HL & Rosenthal N (2001). Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle. Nat Genet 27, 195200.
  • Owino V, Yang SY & Goldspink G (2001). Age-related loss of skeletal muscle function and the inability to express the autocrine form of insulin-like growth factor-1 (MGF) in response to mechanical overload. FEBS Lett 505, 259263.
  • Papadakis MA, Grady D, Black D, Tierney MJ, Gooding GA, Schambelan M & Grunfeld C (1996). Growth hormone replacement in healthy older men improves body composition but not functional ability. Ann Intern Med 124, 708716.
  • Psilander N, Damsgaard R & Pilegaard H (2003). Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle. J Appl Physiol 95, 10381044.
  • Pyka G, Taaffe DR & Marcus R (1994). Effect of a sustained program of resistance training on the acute growth hormone response to resistance exercise in older adults. Horm Metab Res 26, 330333.
  • Rotwein P (1986). Two insulin-like growth factor I messenger RNAs are expressed in human liver. Proc Natl Acad Sci U S A 83, 7781.
  • Rudman D, Feller AG, Nagraj HS, Gergans GA, Lalitha PY, Goldberg AF, Schlenker RA, Cohn L, Rudman IW & Mattson DE (1990). Effects of human growth hormone in men over 60 years old. N Engl J Med 323, 16.
  • Rudman D, Kutner MH, Rogers CM, Lubin MF, Fleming GA & Bain RP (1981). Impaired growth hormone secretion in the adult population: relation to age and adiposity. J Clin Invest 67, 13611369.
  • Sadowski CL, Wheeler TT, Wang LH & Sadowski HB (2001). GH regulation of IGF-I and suppressor of cytokine signaling gene expression in C2C12 skeletal muscle cells. Endocrinology 142, 38903900.
  • Singh MA, Ding W, Manfredi TJ, Solares GS, O'Neill EF, Clements KM, Ryan ND, Kehayias JJ, Fielding RA & Evans WJ (1999). Insulin-like growth factor I in skeletal muscle after weight-lifting exercise in frail elders. Am J Physiol 277, E135E143.
  • Stewart CE & Rotwein P (1996). Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 76, 10051026.
  • Taaffe DR, Jin IH, Vu TH, Hoffman AR & Marcus R (1996). Lack of effect of recombinant human growth hormone (GH). on muscle morphology and GH-insulin-like growth factor expression in resistance-trained elderly men. J Clin Endocrinol Metab 81, 421425.
  • Taaffe DR, Pruitt L, Reim J, Hintz RL, Butterfield G, Hoffman AR & Marcus R (1994). Effect of recombinant human growth hormone on the muscle strength response to resistance exercise in elderly men. J Clin Endocrinol Metab 79, 13611366.
  • Thomas MJ, Kikuchi K, Bichell DP & Rotwein P (1995). Characterization of deoxyribonucleic acid–protein interactions at a growth hormone-inducible nuclease hypersensitive site in the rat insulin-like growth factor-I gene. Endocrinology 136, 562569.
  • Turner JD, Rotwein P, Novakofski J & Bechtel PJ (1988). Induction of mRNA for IGF-I and – II during growth hormone-stimulated muscle hypertrophy. Am J Physiol 255, E513E517.
  • Welle S & Thornton C (1997). Insulin-like growth factor-I, actin, and myosin heavy chain messenger RNAs in skeletal muscle after an injection of growth hormone in subjects over 60 years old. J Endocrinol 155, 9397.
  • Welle S, Thornton C, Statt M & McHenry B (1996). Growth hormone increases muscle mass and strength but does not rejuvenate myofibrillar protein synthesis in healthy subjects over 60 years old. J Clin Endocrinol Metab 81, 32393243.
  • Yang S, Alnaqeeb M, Simpson H & Goldspink G (1996). Cloning and characterization of an IGF-1 isoform expressed in skeletal muscle subjected to stretch. J Muscle Res Cell Motil 17, 487495.
  • Yang SY & Goldspink G (2002). Different roles of the IGF-I Ec peptide (MGF) and mature IGF-I in myoblast proliferation and differentiation. FEBS Lett 522, 156160.
  • Yarasheski KE, Campbell JA, Smith K, Rennie MJ, Holloszy JO & Bier DM (1992). Effect of growth hormone and resistance exercise on muscle growth in young men. Am J Physiol 262, E261E267.
  • Yarasheski KE, Zachwieja JJ, Campbell JA & Bier DM (1995). Effect of growth hormone and resistance exercise on muscle growth and strength in older men. Am J Physiol 268, E268E276.
  • Zaccaria M, Varnier M, Piazza P, Noventa D & Ermolao A (1999). Blunted growth hormone response to maximal exercise in middle-aged versus young subjects and no effect of endurance training. J Clin Endocrinol Metab 84, 23032307.