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A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain
Article first published online: 12 JAN 2004
DOI: 10.1113/jphysiol.2003.055053
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How to Cite
Dalsgaard, M. K., Quistorff, B., Danielsen, E. R., Selmer, C., Vogelsang, T. and Secher, N. H. (2004), A reduced cerebral metabolic ratio in exercise reflects metabolism and not accumulation of lactate within the human brain. The Journal of Physiology, 554: 571–578. doi: 10.1113/jphysiol.2003.055053
Publication History
- Issue published online: 12 JAN 2004
- Article first published online: 12 JAN 2004
- (Resubmitted 11 September 2003; accepted after revision 3 November 2003; first published online 7 November 2003)
References
- , , , , , , , , , , & (2002). Striking differences in glucose and lactate levels between brain extracellular fluid and plasma in conscious human subjects: effects of hyperglycemia and hypoglycemia. J Cereb Blood Flow Metab 22, 271–279.
- & (1972). Brain substrate utilization during prolonged exercise. Scand J Clin Laboratory Invest 29, 397–402.
- , , , , , , , , & (1990). Substrate availability other than glucose in the brain during euglycemia and insulin-induced hypoglycemia in dogs. Metabolism 39, 46–50.
- (1970). Perceived exertion as an indicator of somatic stress. Scand J Rehabil Med 2, 92–98.
- , & (2003). Glycogen regulation and functional role in mouse white matter. J Physiol 549, 501–512.
- , , & (2001). In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia. J Cereb Blood Flow Metab 21, 653–663.
- , & (2003). Effect of hypoglycemia on brain glycogen metabolism in vivo. J Neurosci Res 72, 25–32.
- & (2002). High glycogen levels in brains of rats with minimal environmental stimuli: implications for metabolic contributions of working astrocytes. J Cereb Blood Flow Metab 22, 1476–1489.
- , , & (1992). Localized magnetic resonance spectroscopy measurement of brain lactate during intravenous lactate infusion in healthy volunteers. Life Sci 51, 973–985.
- , , , & (2002). The intent to exercise influences the cerebral O2/carbohydrate uptake ratio in humans. J Physiol 540, 681–689.
- , , & (2003). Cerebral metabolism is influenced by muscle ischaemia during exercise in humans. Exp Physiol 88, 297–302.Direct Link:
- , , & (1990). Effects of stress and exercise on rat hippocampus and striatum extracellular lactate. Am J Physiol 259, R773–R779.
- , , , , & (2001).Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine. J Physiol 533, 849–859.
- , & (2002). Generalized sensory stimulation of conscious rats increases labeling of oxidative pathways of glucose metabolism when the brain glucose-oxygen uptake ratio rises. J Cereb Blood Flow Metab 22, 1490–1502.
- , , & (1995). Lactate transport in cultured glial cells. Dev Neurosci 17, 63–69.
- , , & (1988). Nonoxidative glucose consumption during focal physiologic neural activity. Science 241, 462–464.
- , , , , & (1994). Brain metabolism during short-term starvation in humans. J Cereb Blood Flow Metab 14, 125–131.
- , , , & (2000). Lactate, glucose and O2 uptake in human brain during recovery from maximal exercise. J Physiol 522, 159–164.
- , , , , & (1998). Intravenous lactate prevents cerebral dysfunction during hypoglycaemia in insulin-dependent diabetes mellitus. Clin Sci 94, 157–163.
- , , , & (1998). Monocarboxylate transporter expression in mouse brain. Am J Physiol Endocrinol Metab 275, E516–E524.
- (1995). Lactate metabolism and its effects on glucose metabolism in an excised neural tissue. J Neurochem 64, 1734–1741.
- (1996). Partitioning of CO2 production between glucose and lactate in excised sympathetic ganglia, with implications for brain. J Neurochem 67, 1726–1734.
- , & (1995a). Metabolite flux to and from brain and levels of metabolites in brain of rats during rest, sensory stimulation, and recovery. J Cereb Blood Flow Metab 15, S77.
- , , & (1999). Cerebral oxygen/glucose ratio is low during sensory stimulation and rises above normal during recovery: excess glucose consumption during stimulation is not accounted for by lactate efflux from or accumulation in brain tissue. J Cereb Blood Flow Metab 19, 393–400.
- , , , , , , , & (1995b). Persistent resetting of the cerebral oxygen/glucose uptake ratio by brain activation: evidence obtained with the Kety-Schmidt technique. J Cereb Blood Flow Metab 15, 485–491.
- & (1997). Metabolic coupling during activation. A cellular view. Adv Exp Med Biol 413, 161–166.
- , , , & (1993). Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187, 219–227.
- , , , , & (2002). Bicarbonate attenuates arterial desaturation during maximal exercise in humans. J Appl Physiol 93, 724.
- , & (1992). Neuroendocrine regulatory mechanisms in the choroid plexus-cerebrospinal fluid system. Brain Res Brain Res Rev 17, 109–138.
- , , , & (2002). Effects of hyperthermia on cerebral blood flow and metabolism during prolonged exercise in humans. J Appl Physiol 93, 58–64.
- , , , & (2003). Neurohumoral responses during prolonged exercise in humans. J Appl Physiol 95, 1125–1131.
- & (1994). Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization. Proc Natl Acad Sci U S A 91, 10625–10629.
- & (1967). Blood and cerebrospinalfluid lactate during hyperventilation. Am J Physiol 212, 864–870.
- (1993). Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 30, 672–679.Direct Link:
- , , , , , , & (1991). Cerebral lactate uptake during cardiopulmonary resuscitation in humans. J Cereb Blood Flow Metab 11, 479–484.
- , , & (1999). Open heart surgery; pump prime effects and cerebral arteriovenous differences in glucose, lactate and ketones. Paediatr Anaesth 9, 53–59.
- , , , , & (1992). Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 12, 584–592.
- , , & (2002). Activation-induced resetting of cerebral metabolism and flow is abolished by beta-adrenergic blockade with propranolol. Stroke 33, 251–255.
- , & (1988). Lactate-supported synaptic function in the rat hippocampal slice preparation. Science 240, 1326–1328.
- , & (2001). Cerebral energetics and the glycogen shunt: neurochemical basis of functional imaging. Proc Natl Acad Sci U S A 98, 6417–6422.
- , , , , & (2003). Lactate: a preferred fuel for human brain metabolism in vivo. J Cereb Blood Flow Metab 23, 658–664.
- & (1996). Metabolic coupling between glia and neurons. J Neurosci 16, 877–885.
- , , , & (1994). Effect of hyperketonemia and hyperlacticacidemia on symptoms, cognitive dysfunction, and counterregulatory hormone responses during hypoglycemia in normal humans. Diabetes 43, 1311–1317.
- , , , & (1999). Activation of the insular cortex is affected by the intensity of exercise. J Appl Physiol 87, 1213–1219.
- , , , , , & (1987). Cerebrospinal fluid lactate in patients with hepatic encephalopathy. Eur Neurol 27, 182–187.

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