- Top of page
- Fetal respiratory activity in rodent preparations
- Ontogeny of the pre-Bötzinger complex
- Neurochemical control of fetal respiratory rhythm
- Prenatal maturation of respiratory motoneurones and muscle
- Summary and future perspectives
By birth, the regulatory neural network responsible for respiratory control is capable of generating robust rhythm-driving ventilation that can adjust to homeostatic needs. The advent of in vitro models isolated from prenatal rodents has significantly advanced our understanding of these processes. In this topical review, we examine the development of medullary respiratory rhythm-generating centres and phrenic motoneurone–diaphragm properties during the prenatal period.