SEARCH

SEARCH BY CITATION

References

  • Akiyama M, Yuasa T, Hayasaka N, Horikawa K, Sakurai T & Shibata S (2004). Reduced food anticipatory activity in genetically orexin (hypocretin) neuron-ablated mice. Eur J Neurosci 20, 30543062.
  • Arnulf I, Lin L, Zhang J, Russell IJ, Ripley B, Einen M, Nevsimalova S, Bassetti C, Bourgin P, Nishino S & Mignot E (2006). CSF versus serum leptin in narcolepsy: is there an effect of hypocretin deficiency? Sleep 29, 10171024.
  • Asakawa A, Inui A, Goto K, Yuzuriha H, Takimoto Y, Inui T, Katsuura G, Fujino MA, Meguid MM & Kasuga M (2002). Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice. Int J Mol Med 10, 523525.
  • Beuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T & Yanagisawa M (2004). Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci 24, 44694477.
  • Beuckmann CT & Yanagisawa M (2002). Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J Mol Med 80, 329342.
  • Burdakov D, Jensen LT, Alexopoulos H, Williams RH, Fearon IM, O'Kelly I, Gerasimenko O, Fugger L & Verkhratsky A (2006). Tandem-pore K+ channels mediate inhibition of orexin neurons by glucose. Neuron 50, 711722.
  • Cai XJ, Evans ML, Lister CA, Leslie RA, Arch JR, Wilson S & Williams G (2001). Hypoglycemia activates orexin neurons and selectively increases hypothalamic orexin-B levels: responses inhibited by feeding and possibly mediated by the nucleus of the solitary tract. Diabetes 50, 105112.
  • Chemelli RM, Willie JT, Sinton CM, Elmquist JK, Scammell T, Lee C, Richardson JA, Williams SC, Xiong Y, Kisanuki Y, Fitch TE, Nakazato M, Hammer RE, Saper CB & Yanagisawa M (1999). Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437451.
  • Chou TC, Lee CE, Lu J, Elmquist JK, Hara J, Willie JT, Beuckmann CT, Chemelli RM, Sakurai T, Yanagisawa M, Saper CB & Scammell TE (2001). Orexin (hypocretin) neurons contain dynorphin. J Neurosci 21, RC168.
  • Dahmen N, Bierbrauer J & Kasten M (2001). Increased prevalence of obesity in narcoleptic patients and relatives. Eur Arch Psychiatry Clin Neurosci 251, 8589.
  • De Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS, Frankel WN, Van Den Pol AN, Bloom FE, Gautvik KM & Sutcliffe JG (1998). The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci U S A 95, 322327.
  • Diano S, Horvath B, Urbanski HF, Sotonyi P & Horvath TL (2003). Fasting activates the nonhuman primate hypocretin (orexin) system and its postsynaptic targets. Endocrinology 144, 37743778.
  • Dube MG, Kalra SP & Kalra PS (1999). Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 842, 473477.
  • Edwards CM, Abusnana S, Sunter D, Murphy KG, Ghatei MA & Bloom SR (1999). The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 160, R7R12.
  • Espana RA, Baldo BA, Kelley AE & Berridge CW (2001). Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action. Neuroscience 106, 699715.
  • Fujiki N, Yoshida Y, Ripley B, Honda K, Mignot E & Nishino S (2001). Changes in CSF hypocretin-1 (orexin A) levels in rats across 24 hours and in response to food deprivation. Neuroreport 12, 993997.
  • Fujiki N, Yoshida Y, Zhang S, Sakurai T, Yanagisawa M & Nishino S (2006). Sex difference in body weight gain and leptin signaling in hypocretin/orexin deficient mouse models. Peptides 27, 23262331.
  • Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M & Sakurai T (2001). Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30, 345354.
  • Hara J, Yanagisawa M & Sakurai T (2005). Difference in obesity phenotype between orexin-knockout mice and orexin neuron-deficient mice with same genetic background and environmental conditions. Neurosci Lett 380, 239242.
  • Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M & Arch JR (1999). Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20, 10991105.
  • Ida T, Nakahara K, Katayama T, Murakami N & Nakazato M (1999). Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioral activities of rats. Brain Res 821, 526529.
  • Jobst EE, Enriori PJ & Cowley MA (2004). The electrophysiology of feeding circuits. Trends Endocrinol Metab 15, 488499.
  • Kaitin KI, Kilduff TS & Dement WC (1986). Sleep fragmentation in canine narcolepsy. Sleep 9, 116119.
  • Kiwaki K, Kotz CM, Wang C, Lanningham-Foster L & Levine JA (2004). Orexin A (hypocretin 1) injected into hypothalamic paraventricular nucleus and spontaneous physical activity in rats. Am J Physiol Endocrinol Metab 286, E551E559.
  • Kotz CM, Teske JA, Levine JA & Wang C (2002). Feeding and activity induced by orexin A in the lateral hypothalamus in rats. Regul Pept 104, 2732.
  • Kunii K, Yamanaka A, Nambu T, Matsuzaki I, Goto K & Sakurai T (1999). Orexins/hypocretins regulate drinking behaviour. Brain Res 842, 256261.
  • Lammers GJ, Pijl H, Iestra J, Langius JA, Buunk G & Meinders AE (1996). Spontaneous food choice in narcolepsy. Sleep 19, 7576.
  • Lin L, Faraco J, Li R, Kadotani H, Rogers W, Lin X, Qiu X, De Jong PJ, Nishino S & Mignot E (1999). The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365376.
  • Lubkin M & Stricker-Krongrad A (1998). Independent feeding and metabolic actions of orexins in mice. Biochem Biophys Res Commun 253, 241245.
  • Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M & Elmquist JK (2001). Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435, 625.
  • Mieda M, Williams SC, Sinton CM, Richardson JA, Sakurai T & Yanagisawa M (2004). Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci 24, 1049310501.
  • Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T & Scammell TE (2004). Behavioral state instability in orexin knock-out mice. J Neurosci 24, 62916300.
  • Mochizuki T, Klerman EB, Sakurai T & Scammell TE (2006). Elevated body temperature during sleep in orexin knockout mice. Am J Physiol Regul Integr Comp Physiol 291, R533540.
  • Monda M, Viggiano A & De Mondola P & V (2001). Inhibition of prostaglandin synthesis reduces hyperthermic reactions induced by hypocretin-1/orexin A. Brain Res 909, 6874.
  • Moriguchi T, Sakurai T, Nambu T, Yanagisawa M & Goto K (1999). Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia. Neurosci Lett 264, 101104.
  • Nilaweera KN, Barrett P, Mercer JG & Morgan PJ (2003). Precursor-protein convertase 1 gene expression in the mouse hypothalamus: differential regulation by ob gene mutation, energy deficit and administration of leptin, and coexpression with prepro-orexin. Neuroscience 119, 713720.
  • Nishino S, Ripley B, Overeem S, Nevsimalova S, Lammers GJ, Vankova J, Okun M, Rogers W, Brooks S & Mignot E (2001). Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 50, 381388.
  • Olszewski PK, Li D, Grace MK, Billington CJ, Kotz CM & Levine AS (2003). Neural basis of orexigenic effects of ghrelin acting within lateral hypothalamus. Peptides 24, 597602.
  • Peyron C, Faraco J, Rogers W, Ripley B, Overeem S, Charnay Y, Nevsimalova S, Aldrich M, Reynolds D, Albin R, Li R, Hungs M, Pedrazzoli M, Padigaru M, Kucherlapati M, Fan J, Maki R, Lammers GJ, Bouras C, Kucherlapati R, Nishino S & Mignot E (2000). A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat Med 6, 991997.
  • Reti IM, Reddy R, Worley PF & Baraban JM (2002). Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons. J Neurochem 82, 15611565.
  • Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR & Blundell JE (2000). Dose–response effects of orexin-A on food intake and the behavioural satiety sequence in rats. Regul Pept 96, 7184.
  • Rodgers RJ, Halford JC, Nunes de Souza RL, Canto de Souza AL, Piper DC, Arch JR, Upton N, Porter RA, Johns A & Blundell JE (2001). SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci 13, 14441452.
  • Sakurai T (2006). Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis. CNS Neurol Disord Drug Targets 5, 313325.
  • Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ & Yanagisawa M (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573585.
  • Schuld A, Hebebrand J, Geller F & Pollmacher T (2000). Increased body-mass index in patients with narcolepsy. Lancet 355, 12741275.
  • Smart D, Haynes AC, Williams G & Arch JR (2002). Orexins and the treatment of obesity. Eur J Pharmacol 440, 199212.
  • Sweet DC, Levine AS, Billington CJ & Kotz CM (1999). Feeding response to central orexins. Brain Res 821, 535538.
  • Taheri S, Zeitzer JM & Mignot E (2002). The role of hypocretins (orexins) in sleep regulation and narcolepsy. Annu Rev Neurosci 25, 283313.
  • Tang X & Sanford LD (2002). Telemetric recording of sleep and home cage activity in mice. Sleep 25, 691699.
  • Thannickal TC, Moore RY, Nienhuis R, Ramanathan L, Gulyani S, Aldrich M, Cornford M & Siegel JM (2000). Reduced number of hypocretin neurons in human narcolepsy. Neuron 27, 469474.
  • Wang J, Osaka T & Inoue S (2001). Energy expenditure by intracerebroventricular administration of orexin to anesthetized rats. Neurosci Lett 315, 4952.
  • Willie JT, Chemelli RM, Sinton CM & Yanagisawa M (2001). To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Annu Rev Neurosci 24, 429458.
  • Yamanaka A, Beuckmann CT, Willie JT, Hara J, Tsujino N, Mieda M, Tominaga M, Yagami K, Sugiyama F, Goto K, Yanagisawa M & Sakurai T (2003). Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701713.
  • Yoshida Y, Fujiki N, Nakajima T, Ripley B, Matsumura H, Yoneda H, Mignot E & Nishino S (2001). Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur J Neurosci 14, 10751081.
  • Zhang S, Zeitzer JM, Yoshida Y, Wisor JP, Nishino S, Edgar DM & Mignot E (2004). Lesions of the suprachiasmatic nucleus eliminate the daily rhythm of hypocretin-1 release. Sleep 27, 619627.