This paper has online supplemental material.
Cell-specific spike-timing-dependent plasticity in GABAergic and cholinergic interneurons in corticostriatal rat brain slices
Version of Record online: 2 JAN 2008
© 2008 The Journal of Physiology © 2008 The Physiological Society
The Journal of Physiology
Volume 586, Issue 1, pages 265–282, January 2008
How to Cite
Fino, E., Deniau, J.-M. and Venance, L. (2008), Cell-specific spike-timing-dependent plasticity in GABAergic and cholinergic interneurons in corticostriatal rat brain slices. The Journal of Physiology, 586: 265–282. doi: 10.1113/jphysiol.2007.144501
- Issue online: 2 JAN 2008
- Version of Record online: 2 JAN 2008
- (Received 4 September 2007; accepted after revision 29 October 2007; first published online 1 November 2007)
Figure 1: Averages of normalized EPSC amplitudes recorded in control before STDP protocols for fast-spiking GABAergic interneurons for postpre protocols (A) (n=10) and pre-post protocols (B) (n=10), and for cholinergic interneurons for post-pre protocols (C) (n=17) and pre-post protocols (D) (n=12). Control EPSC amplitudes were recorded for 10 minutes (minus sign indicates time before the cellular conditioning protocol) and displayed no significant variation.
Figure 2: Temporal sequence of activation of striatal neurons in response to a cortical stimulation. A cortical stimulation induced the following sequence of activation: first fast-spiking GABAergic interneurons, second cholinergic interneurons and finally MSNs. This is illustrated by (A) latencies and (B) rise times of striatal neurons in response to a cortical stimulation. MSN data are taken from Fino et al. (2005) study.
Figure 3: The magnitudes of long-term synaptic efficacy changes induced by post-pre protocol on cholinergic interneurons were plotted against EPSC rise time in control (A), input resistance (B) and RMP (C). No significant correlation was found between these parameters and the magnitude of LTP or LTD induced by post-pre protocols (r values are indicated in each graph).
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