This report was presented at The Journal of Physiology Symposium on Retinal ganglion cells in model organisms: development, function and disease, which took place in Fort Lauderdale, FL, USA, 26 April 2008. It was commissioned by the Editorial Board and reflects the views of the authors.
Retinal ganglion cells in diabetes
Article first published online: 15 SEP 2008
© 2008 The Authors. Journal compilation © 2008 The Physiological Society
The Journal of Physiology
Volume 586, Issue 18, pages 4401–4408, September 2008
How to Cite
Kern, T. S. and Barber, A. J. (2008), Retinal ganglion cells in diabetes. The Journal of Physiology, 586: 4401–4408. doi: 10.1113/jphysiol.2008.156695
- Issue published online: 15 SEP 2008
- Article first published online: 15 SEP 2008
- (Received 10 May 2008; accepted after revision 4 June 2008; first published online 19 June 2008)
Diabetic retinopathy has long been recognized as a vascular disease that develops in most patients, and it was believed that the visual dysfunction that develops in some diabetics was due to the vascular lesions used to characterize the disease. It is becoming increasingly clear that neuronal cells of the retina also are affected by diabetes, resulting in dysfunction and even degeneration of some neuronal cells. Retinal ganglion cells (RGCs) are the best studied of the retinal neurons with respect to the effect of diabetes. Although investigations are providing new information about RGCs in diabetes, including therapies to inhibit the neurodegeneration, critical information about the function, anatomy and response properties of these cells is yet needed to understand the relationship between RGC changes and visual dysfunction in diabetes.