- Top of page
- Neurological channelopathies in 2010: a snapshot
- A genetic conundrum
- Why do so many channelopathies have paroxysmal manifestations?
- Why is clinical onset in some channelopathies delayed?
- Channelopathies are leading to fundamental advances in ion channel research
Inherited mutations of ion channels provide unique insights into the mechanisms of many neurological diseases. However, they also provide a wealth of new information on the fundamental biology of ion channels and on neuron and muscle function. Ion channel genes are continuing to be discovered by positional cloning of disease loci. And some mutations provide unique tools to manipulate signalling cascades, which cannot be achieved by pharmacological intervention. Here we highlight some unanswered questions, and some promising areas for research that will likely lead to a fuller understanding of the link from molecular lesion to disease.