This review is from the symposium Exercise metabolism at The Biomedical Basis of Elite Performance, a joint meeting of The Physiological Society and the British Pharmacological Society, together with The Journal of Physiology, Experimental Physiology, British Journal of Pharmacology and The Scandinavian Journal of Medicine and Science in Sports, at the Queen Elizabeth Hall, London on 20 March 2012.
Regulation of glucose and glycogen metabolism during and after exercise
Article first published online: 1 MAR 2012
© 2012 The Authors. The Journal of Physiology © 2012 The Physiological Society
The Journal of Physiology
Volume 590, Issue 5, pages 1069–1076, March 2012
How to Cite
Jensen, T. E. and Richter, E. A. (2012), Regulation of glucose and glycogen metabolism during and after exercise. The Journal of Physiology, 590: 1069–1076. doi: 10.1113/jphysiol.2011.224972
- Issue published online: 1 MAR 2012
- Article first published online: 1 MAR 2012
- Accepted manuscript online: 28 DEC 2011 03:50PM EST
- (Received 21 November 2011; accepted after revision 21 December 2011; first published online 23 December 2011)
Abstract Utilization of carbohydrate in the form of intramuscular glycogen stores and glucose delivered from plasma becomes an increasingly important energy substrate to the working muscle with increasing exercise intensity. This review gives an update on the molecular signals by which glucose transport is increased in the contracting muscle followed by a discussion of glycogen mobilization and synthesis by the action of glycogen phosphorylase and glycogen synthase, respectively. Finally, this review deals with the signalling relaying the well-described increased sensitivity of glucose transport to insulin in the post-exercise period which can result in an overshoot of intramuscular glycogen resynthesis post exercise (glycogen supercompensation).