Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals
Article first published online: 9 JAN 2013
© 2013 The Authors. The Journal of Physiology © 2013 The Physiological Society
The Journal of Physiology
Volume 591, Issue 7, pages 1859–1870, April 2013
How to Cite
Fisher, J. P., Hartwich, D., Seifert, T., Olesen, N. D., McNulty, C. L., Nielsen, H. B., van Lieshout, J. J. and Secher, N. H. (2013), Cerebral perfusion, oxygenation and metabolism during exercise in young and elderly individuals. The Journal of Physiology, 591: 1859–1870. doi: 10.1113/jphysiol.2012.244905
- Issue published online: 27 MAR 2013
- Article first published online: 9 JAN 2013
- Accepted manuscript online: 11 DEC 2012 10:11AM EST
- (Received 13 September 2012; accepted after revision 4 December 2012; first published online 10 December 2012)
- • The influence of normative ageing on cerebral perfusion, oxygenation and metabolism during exercise is not well known.
- • This study assessed cerebral perfusion and concentration differences for oxygen, glucose and lactate across the brain, in young and elderly individuals at rest and during incremental exercise to exhaustion.
- • We observed that during submaximal exercise (at matched relative intensities) and during maximal exercise, cerebral perfusion was reduced in older individuals compared with young individuals, while the cerebral metabolic rate for oxygen and uptake of glucose and lactate were similar.
- • The results indicate that the age-related reduction in cerebral perfusion during exercise does not affect brain uptake of lactate and glucose.
Abstract We evaluated cerebral perfusion, oxygenation and metabolism in 11 young (22 ± 1 years) and nine older (66 ± 2 years) individuals at rest and during cycling exercise at low (25%Wmax), moderate (50%Wmax), high (75%Wmax) and exhaustive (100%Wmax) workloads. Mean middle cerebral artery blood velocity (MCA Vmean), mean arterial pressure (MAP), cardiac output (CO) and partial pressure of arterial carbon dioxide () were measured. Blood samples were obtained from the right internal jugular vein and brachial artery to determine concentration differences for oxygen (O2), glucose and lactate across the brain. The molar ratio between cerebral uptake of O2 versus carbohydrate (O2–carbohydrate index; O2/[glucose +1/2 lactate]; OCI), the cerebral metabolic rate of O2 (CMRO2) and changes in mitochondrial O2 tension () were calculated. 100%Wmax was ∼33% lower in the older group. Exercise increased MAP and CO in both groups (P < 0.05 vs. rest), but at each intensity MAP was higher and CO lower in the older group (P < 0.05). MCA Vmean, and cerebral vascular conductance index (MCA Vmean/MAP) were lower in the older group at each exercise intensity (P < 0.05). In contrast, young and older individuals exhibited similar increases in CMRO2 (by ∼30 μmol (100 g−1) min−1), and decreases in OCI (by ∼1.5) and (by ∼10 mmHg) during exercise at ≥75%Wmax. Thus, despite the older group having reduced cerebral perfusion and maximal exercise capacity, cerebral oxygenation and uptake of lactate and glucose are similar during exercise in young and older individuals.