This report was presented at the Cardiac & Respiratory Physiology Themed Meeting of The Physiological Society, Manchester, UK, 4–6 September 2012.
Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?
Article first published online: 7 JUN 2013
© 2013 The Authors. The Journal of Physiology © 2013 The Physiological Society
The Journal of Physiology
Special Issue: Special cardiovascular issue
Volume 591, Issue 17, pages 4141–4147, September 2013
How to Cite
Orchard, C. H., Bryant, S. M. and James, A. F. (2013), Do t-tubules play a role in arrhythmogenesis in cardiac ventricular myocytes?. The Journal of Physiology, 591: 4141–4147. doi: 10.1113/jphysiol.2013.254540
- Issue published online: 30 AUG 2013
- Article first published online: 7 JUN 2013
- Accepted manuscript online: 15 MAY 2013 02:26PM EST
- (Received 11 March 2013; accepted after revision 5 May 2013; first published online 7 May 2013)
Abstract The transverse (t-) tubules of mammalian ventricular myocytes are invaginations of the surface membrane. The function of many of the key proteins involved in excitation–contraction coupling is located predominantly at the t-tubules, which thus form a Ca2+-handling micro-environment that is central to the normal rapid activation and relaxation of the ventricular myocyte. Although cellular arrhythmogenesis shares many ion flux pathways with normal excitation–contraction coupling, the role of the t-tubules in such arrhythmogenesis has not previously been considered. In this brief review we consider how the location and co-location of proteins at the t-tubules may contribute to the generation of arrhythmogenic delayed and early afterdepolarisations, and how the loss of t-tubules that occurs during heart failure may alter the generation of such arrhythmias, as well as contributing to other types of arrhythmia as a result of changes of electrical heterogeneity within the whole heart.