Intravascular pressure augments cerebral arterial constriction by inducing voltage-insensitive Ca2+ waves (pages 3983–4005)
Rania E. Mufti, Suzanne E. Brett, Cam Ha T. Tran, Rasha Abd El-Rahman, Yana Anfinogenova, Ahmed El-Yazbi, William C. Cole, Peter P. Jones, S.R. Wayne Chen and Donald G. Welsh
Version of Record online: 14 OCT 2010 | DOI: 10.1113/jphysiol.2010.193300
Tissue blood flow is controlled by a network of resistance arteries. Under normal conditions, the diameter of an artery is regulated by: (1) agents released from nerves and surrounding tissue; and (2) mechanical forces including blood pressure. Bayliss first described the ability of arteries to constrict to blood pressure and since his pioneering work in 1902, studies have been interested in defining the signalling events underlying this important biological response. Using a range of physiological and biochemical techniques, this study showed that Ca2+ waves play an important role in enabling arteries to respond to elevated blood pressure. Ca2+ waves are discrete events that spread in an asynchronous manner from one end of a smooth muscle cell to the other. These events depend on the release of Ca2+ from an internal store called the sarcoplasmic reticulum.