High-altitude pulmonary hypertension is associated with a free radical-mediated reduction in pulmonary nitric oxide bioavailability (pages 4837–4847)
Damian M. Bailey, Christoph Dehnert, Andrew M. Luks, Elmar Menold, Christian Castell, Guido Schendler, Vitalie Faoro, Mariusz Gutowski, Kevin A. Evans, Sarah Taudorf, Philip E. James, J. McEneny, Ian S. Young, Erik R. Swenson, Heimo Mairbäurl, Peter Bärtsch and Marc M. Berger
Version of Record online: 30 NOV 2010 | DOI: 10.1113/jphysiol.2010.194704
What causes pulmonary hypertension at high altitude remains unknown. By measuring the transpulmonary exchange kinetics of redox-reactive biomarkers, this study suggests that hypertension may be related to a free radical-mediated reduction in pulmonary vascular nitric oxide bioavailability due in part to inadequate antioxidant defence. These findings have broader implications for other clinical models of human disease characterised by global hypoxaemia and identify the hypoxic human lungs as a contributory source of oxidative–nitrosative–inflammatory stress.