Intrathecal fentanyl abolishes the exaggerated blood pressure response to cycling in hypertensive men (pages 715–725)
Thales C. Barbosa, Lauro C. Vianna, Igor A. Fernandes, Eliza Prodel, Helena N. M. Rocha, Vinicius P. Garcia, Natalia G. Rocha, Niels H. Secher and Antonio C. L. Nobrega
Article first published online: 15 JAN 2016 | DOI: 10.1113/JP271335
- The increase in blood pressure observed during physical activities is exaggerated in patients with hypertension, exposing them to a higher cardiovascular risk.
- Neural signals from the skeletal muscles appear to be overactive, resulting in this abnormal response in hypertensive patients.
- In the present study, we tested whether the attenuation of these neural signals in hypertensive patients could normalize their abnormal increase in blood pressure during physical activity.
- Attenuation of the neural signals from the leg muscles with intrathecal fentanyl injection reduced the blood pressure of hypertensive men during cycling exercise to a level comparable to that of normotensive men.
- Skeletal muscle afferent overactivity causes the abnormal cardiovascular response to exercise and was reverted in this experimental model, appearing as potential target for treatment.