Dynamic model of the left ventricle for use in simulation of myocardial perfusion SPECT and gated SPECT

Authors

  • Bullich S.,

    1. Unitat de Biofı́sica i Bienginyeria, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
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  • Ros D.,

    1. Unitat de Biofı́sica i Bienginyeria, Facultat de Medicina, Universitat de Barcelona
    2. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Casanova 143, 08036 Barcelona, Spain
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  • Cot A.,

    1. Departament de Fı́sica i Enginyeria Nuclear, Universitat Politècnica de Catalunya, Diagonal 647, 08028 Barcelona, Spain
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  • Falcón C.,

    1. Unitat de Biofı́sica i Bienginyeria, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona, Spain
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  • Muxı́ A.,

    1. Servei de Medicina Nuclear, Hospital Clı́nic i Provincial de Barcelona, Villaroel 170; 08036 Barcelona, Spain
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  • Pavia J.

    1. Servei de Medicina Nuclear, Hospital Clı́nic i Provincial de Barcelona, and Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain
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Abstract

Simulation is a useful tool in cardiac SPECT to assess quantification algorithms. However, simple equation-based models are limited in their ability to simulate realistic heart motion and perfusion. We present a numerical dynamic model of the left ventricle, which allows us to simulate normal and anomalous cardiac cycles, as well as perfusion defects. Bicubic splines were fitted to a number of control points to represent endocardial and epicardial surfaces of the left ventricle. A transformation from each point on the surface to a template of activity was made to represent the myocardial perfusion. Geometry-based and patient-based simulations were performed to illustrate this model. Geometry-based simulations modeled (1) a normal patient, (2) a well-perfused patient with abnormal regional function, (3) an ischaemic patient with abnormal regional function, and (4) a patient study including tracer kinetics. Patient-based simulation consisted of a left ventricle including a realistic shape and motion obtained from a magnetic resonance study. We conclude that this model has the potential to study the influence of several physical parameters and the left ventricle contraction in myocardial perfusion SPECT and gated-SPECT studies.

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