The prevalence of neurodegenerative diseases is growing in western countries and PET imaging is increasingly frequently used for clinical and research purposes. However, few PET cameras are dedicated to cerebral imaging. The Biograph™ 6 (Biograph6) (Siemens Medical Solutions) is a PET/CT dedicated to high throughput whole body studies. Its performance for cerebral imaging has not yet been assessed. The aims of this study were to compare the quantification and detectability of the Biograph for cerebral imaging with those of a well-validated PET camera, the ECAT EXACT () (Siemens Medical Solutions). A phantom measuring long and in diameter was filled with a -fluorodeoxyglucose solution. Two 5.7 and spheres filled with water (cold-spots), three spheres (sphere-to-background: 3, 6, and 12), one sphere (sphere-to-background: 3), and one sphere (sphere-to-background: 2) filled with a radioactive solution were inserted into the phantom. The activity concentration was chosen so that the count rates for the phantom measurements matched those of typical brain studies on both cameras. Images were reconstructed using FORE and OSEM algorithms. The reconstruction parameters were adjusted to obtain a similar signal-to-noise ratio in images acquired with the two cameras. The contrast recovery (CR) coefficients were similar on the two scanners for the 5.7 and spheres (cold spheres) and the 1.14 and spheres (hot spheres). For the spheres, the CR values were 35% higher for the sphere-to-background ratio of 12 and 39% higher for the sphere-to-background ratio of 6 on the Biograph6 for the scan. The variability of measurements was lower on the Biograph6 than on the . The detectability for the smallest spheres on the Biograph6 was close to that on the . The Biograph has similar performances as the reference tomograph for the detection and quantification of small hot spots and cold spots.