Effect of prolonged stimulation on cerebral hemodynamic: A time-resolved fNIRS study

Authors

  • Butti Michele,

    1. Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Contini Davide,

    1. Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Molteni Erika,

    1. Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Caffini Matteo,

    1. Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Spinelli Lorenzo,

    1. National Laboratory for Ultrafast and Ultraintense Optical Science, ULTRAS-INFM-CNR, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Baselli Giuseppe,

    1. Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Bianchi Anna Maria,

    1. Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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    • a)

      Author to whom correspondence should be addressed. Electronic mail: annamaria.bianchi@polimi.it; Present address: via Golgi 39, Campus Leonardo, Edificio 34, Quarto Piano, 20133 Milano, Italy; Telephone: 0039-02-2399-3342; Fax: 0039-02-23993360.

  • Cerutti Sergio,

    1. Dipartimento di Bioingegneria, IIT Unit, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Cubeddu Rinaldo,

    1. Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy; National Laboratory for Ultrafast and Ultraintense Optical Science, ULTRAS-INFM-CNR, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy; Istituto di Fotonica e Nanotecnologie, IFN-CNR, Sezione di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy; and Research Unit IIT, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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  • Torricelli Alessandro

    1. Dipartimento di Fisica, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy and Research Unit IIT, Politecnico di Milano, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy
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Abstract

Purpose:

Sustained attention is one of the most important cognitive abilities for the management of everyday life, but it is often studied only at the behavioral level, while functional correlates are scarcely investigated. In this article, the authors address the topic of characterizing the dynamics of cerebral metabolism in the prefrontal cortex during a task of prolonged attention.

Method:

By means of multichannel time-resolved functional near-infrared spectroscopy and generalized linear model based data processing, the authors measured the hemodynamic response of the prefrontal cortex from 19 healthy subjects to a shortened version of a sustained attention task (Conners’ Continuous Performance Test), lasting for10min.

Results:

The task elicited significant brain activation, which did not remain constant for the entire task, but showed a drop not correlated with performance decay4min after the beginning of the task. Furthermore, oxygenated hemoglobin showed an increasing trend also during the first phase of the recovery, just after the end of the task.

Conclusion:

The results indicate a nontrivial dynamics of neural activation, habituation processes, and hemodynamic/metabolic coupling. These results encourage further studies about continuous stimulation of cognitive functions on both healthy and pathological subjects.

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