Sci—Thur AM: YIS - 11: Estimation of Bladder-Wall Cumulative Dose in Multi-Fraction Image-Based Gynaecological Brachytherapy Using Deformable Point Set Registration

Authors

  • Zakariaee R,

    1. Physics Department, University of British Columbia, Vancouver, BC
    2. School of Computing Science, Simon Fraser University, Burnaby, BC
    3. British Columbia Cancer Agency, Vancouver, BC
    Search for more papers by this author
  • Brown C J,

    1. Physics Department, University of British Columbia, Vancouver, BC
    2. School of Computing Science, Simon Fraser University, Burnaby, BC
    3. British Columbia Cancer Agency, Vancouver, BC
    Search for more papers by this author
  • Hamarneh G,

    1. Physics Department, University of British Columbia, Vancouver, BC
    2. School of Computing Science, Simon Fraser University, Burnaby, BC
    3. British Columbia Cancer Agency, Vancouver, BC
    Search for more papers by this author
  • Parsons C A,

    1. Physics Department, University of British Columbia, Vancouver, BC
    2. School of Computing Science, Simon Fraser University, Burnaby, BC
    3. British Columbia Cancer Agency, Vancouver, BC
    Search for more papers by this author
  • Spadinger I

    1. Physics Department, University of British Columbia, Vancouver, BC
    2. School of Computing Science, Simon Fraser University, Burnaby, BC
    3. British Columbia Cancer Agency, Vancouver, BC
    Search for more papers by this author

Abstract

Dosimetric parameters based on dose-volume histograms (DVH) of contoured structures are routinely used to evaluate dose delivered to target structures and organs at risk. However, the DVH provides no information on the spatial distribution of the dose in situations of repeated fractions with changes in organ shape or size. The aim of this research was to develop methods to more accurately determine geometrically localized, cumulative dose to the bladder wall in intracavitary brachytherapy for cervical cancer. The CT scans and treatment plans of 20 cervical cancer patients were used. Each patient was treated with five high-dose-rate (HDR) brachytherapy fractions of 600cGy prescribed dose. The bladder inner and outer surfaces were delineated using MIM Maestro software (MIM Software Inc.) and were imported into MATLAB (MathWorks) as 3-dimensional point clouds constituting the “bladder wall”. A point-set registration toolbox for MATLAB, Coherent Point Drift (CPD), was used to non-rigidly transform the bladder-wall points from four of the fractions to the coordinate system of the remaining (reference) fraction, which was chosen to be the emptiest bladder for each patient. The doses were accumulated on the reference fraction and new cumulative dosimetric parameters were calculated. The LENT-SOMA toxicity scores of these patients were studied against the cumulative dose parameters. Based on this study, there was no significant correlation between the toxicity scores and the determined cumulative dose parameters.

Ancillary