SU-E-T-266: Development of Evaluation System of Optimal Synchrotron Controlling Parameter for Spot Scanning Proton Therapy with Multiple Gate Irradiations in One Operation Cycle

Authors

  • Yamada T,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Miyamoto N,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Matsuura T,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Takao S,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Matsuzaki Y,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Fujii Y,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Koyano H,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Nihongi H,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Umezawa M,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Matsuda K,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Umegaki K,

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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  • Shirato H

    1. Hokkaido University Hospital, Sapporo, Hokkaido
    2. Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido
    3. Hitachi Ltd., Hitachi-shi, Ibaraki
    4. Faculty of Engineering, Hokkaido University, Sapporo, Hokkaido
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Abstract

Purpose:

We have developed a gated spot scanning proton beam therapy system with real-time tumor-tracking. This system has the ability of multiple-gated irradiation in a single synchrotron operation cycle controlling the wait-time for consecutive gate signals during a flat-top phase so that the decrease in irradiation efficiency induced by irregular variation of gate signal is reduced. Our previous studies have shown that a 200 ms wait-time is appropriate to increase the average irradiation efficiency, but the optimal wait-time can vary patient by patient and day by day. In this research, we have developed an evaluation system of the optimal wait-time in each irradiation based on the log data of the real-time-image gated proton beam therapy (RGPT) system.

Methods:

The developed system consists of logger for operation of RGPT system and software for evaluation of optimal wait-time. The logger records timing of gate on/off, timing and the dose of delivered beam spots, beam energy and timing of X-ray irradiation. The evaluation software calculates irradiation time in the case of different wait-time by simulating the multiple-gated irradiation operation using several timing information. Actual data preserved in the log data are used for gate on and off time, spot irradiation time, and time moving to the next spot. Design values are used for the acceleration and deceleration times. We applied this system to a patient treated with the RGPT system.

Results:

The evaluation system found the optimal wait-time of 390 ms that reduced the irradiation time by about 10 %. The irradiation time with actual wait-time used in treatment was reproduced with accuracy of 0.2 ms.

Conclusion:

For spot scanning proton therapy system with multiple-gated irradiation in one synchrotron operation cycle, an evaluation system of the optimal wait-time in each irradiation based on log data has been developed.

Funding Support: Japan Society for the Promotion of Science (JSPS) through the FIRST Program.

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