MO-FG-BRA-03: A Monte-Carlo Study of Cellular Dosimetry of Radioactive Gold-Palladium Nanoparticles

Authors

  • Ma Y,

    1. CHU de Quebec, Quebec, QC
    2. Rutherford Physics Building, Montreal, Quebec
    3. Hopital Saint-Francois -d'Assise, Quebec, Quebec
    4. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Michaud F,

    1. CHU de Quebec, Quebec, QC
    2. Rutherford Physics Building, Montreal, Quebec
    3. Hopital Saint-Francois -d'Assise, Quebec, Quebec
    4. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Fortin M,

    1. CHU de Quebec, Quebec, QC
    2. Rutherford Physics Building, Montreal, Quebec
    3. Hopital Saint-Francois -d'Assise, Quebec, Quebec
    4. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Beaulieu L

    1. CHU de Quebec, Quebec, QC
    2. Rutherford Physics Building, Montreal, Quebec
    3. Hopital Saint-Francois -d'Assise, Quebec, Quebec
    4. Centre Hospitalier Univ de Quebec, Quebec, QC
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Abstract

Purpose:

Radioactive gold-palladium nanoparticles (13Pd:Pd@Au NPs) are being developed for prostate cancer brachytherapy. Photons emitted by the radioisotope palladium (photon energy: 20.1 and 23.0 keV), interacting with gold-coating of NPs, lead to enhanced energy distribution in nucleus. Here, a simple cellular model was studied using detailed track-structure method.

Methods:

Geant4-DNA was used with auger electrons enabled. Biological cell was modeled as a sphere of radius r=5 µm that were immersed in a fluid containing large number of NPs at different concentrations (S=1, 2.15, 5.1, 17.2 mg-Au/g-H2O). Nucleus was modeled as a concentric sphere (r=3µm). Thickness of gold-coating on 13Pd core was 15nm, 20nm and 25nm, respectively. A scenario of NP diffusion was investigated, where S=5.1 mg-Au/g-H2O outside cell and S=1 mg-Au/g-H2O in cytoplasm. 10113Pd decays were simulated for each combination of NP concentration and gold-coating.

Results:

A uniform increase in energy deposition (Edep) is observed in cell nucleus and the energy enhancement ratio (EER) is 1.16, 1.22 and 1.3 for 15nm, 20nm and 25nm of gold -coatings, respectively. Edep at the center of nucleus is increased by a factor of 1.47, 2.51 and 5.54 when the NP concentration in the cytoplasm increases from 1 mg-Au/g-H2O to 2.15, 5.10 and 17.2 mg-Au/g-H2O, respectively. When NPs diffuse into cytoplasm, the mean value of Edep in nucleus increases from 0.42 to 1.13 MeV per 10⁹ decays (GBq-Second) of 13Pd and the maximum value increases from 0.54 to 2.5 MeV per GBq-Second.

Conclusion:

These results suggest that 13Pd:Pd@Au NPs constitute a promising nanotherapeutic agent. Ongoing studies use transmission electron microscopy (TEM) images of prostate cancer.

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