TU-EF-304-04: A Heart Motion Model for Proton Scanned Beam Chest Radiotherapy

Authors

  • White B,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Kiely J Blanco,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Vennarini S,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Lin L,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Freedman G,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Santhanam A,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Low D,

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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  • Both S

    1. University of Pennsylvania, Philadelphia, PA
    2. Operativa di Protonterapia, Azienda Provinciale per i Servizi Sanitari, Trento, Trento
    3. University of California, Los Angeles, Los Angeles, CA
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Abstract

Purpose:

To model fast-moving heart surface motion as a function of cardiac-phase in order to compensate for the lack of cardiac-gating in evaluating accurate dose to coronary structures.

Methods:

Ten subjects were prospectively imaged with a breath-hold, cardiac-gated MRI protocol to determine heart surface motion. Radial and planar views of the heart were resampled into a 3-dimensional volume representing one heartbeat. A multi-resolution optical flow deformable image registration algorithm determined tissue displacement during the cardiac-cycle. The surface of the heart was modeled as a thin membrane comprised of voxels perpendicular to a pencil beam scanning (PBS) beam. The membrane's out-of-plane spatial displacement was modeled as a harmonic function with Lame's equations. Model accuracy was assessed with the root mean squared error (RMSE). The model was applied to a cohort of six chest wall irradiation patients with PBS plans generated on phase-sorted 4DCT. Respiratory motion was separated from the cardiac motion with a previously published technique. Volumetric dose painting was simulated and dose accumulated to validate plan robustness (target coverage variation accepted within 2%). Maximum and mean heart surface dose assessed the dosimetric impact of heart and coronary artery motion.

Results:

Average and maximum heart surface displacements were 2.54±0.35mm and 3.6mm from the end-diastole phase to the end-systole cardiac-phase respectively. An average RMSE of 0.11±0.04 showed the model to be accurate. Observed errors were greatest between the circumflex artery and mitral valve level of the heart anatomy. Heart surface displacements correspond to a 3.6±1.0% and 5.1±2.3% dosimetric impact on the maximum and mean heart surface DVH indicators respectively.

Conclusion:

Although heart surface motion parallel to beam's direction was substantial, its maximum dosimetric impact was 5.1±2.3%. Since PBS delivers low doses to coronary structures relative to photon radiotherapy, it is unknown whether this variation would be clinically significant for late effects.

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