TU-EF-303-03: Single Cell Measurements of Tanscription Heterogeneity of Highly Mobile Identical Genes

Authors


Abstract

Many medical physics diagnostic and therapeutic developments have significant overlap with biophysical approaches to measuring and modeling molecular and cellular systems. Although these methods may differ dramatically in terms of temporal and spatial scales, many of the underlying concepts are identical, suggesting potential synergies across the scales. For example, while clinical imaging is typically in the (sub)millimeter and second regime, biophysical imaging technologies reach sub-nanometer and sub-picosecond scales. Despite these scale differences, the use of molecular labeling, resulting large datasets, and need for quantitative analysis methods are similar, and solutions developed for one application are easily translated to others. Similarly, mathematical models used to understand clinical responses are often based on molecular and cellular networks that have been elucidated by biophysical studies. In turn, such models are directly useful for guiding on-going biophysical and biomedical research. Relevant biophysical applications are found in the cancer, neuroscience, and cardiac fields, which are also research focus areas for many AAPM members. Presentations by physicists working in biophysics will explore potential synergies with diagnostic and therapeutic medical physics, as well as help identify areas of common interest that would be ripe for novel collaborations.

Learning Objectives:

  • 1.1.To learn about differences in temporal and spatial scales of medical physics and biophysics
  • 2.To learn about common methods used in medical physics and biophysics
  • 3.To learn about synergistic opportunities between medical physics and biophysics

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