TH-AB-BRA-02: Generation of 3D Dosimetric Reference Datasets for Commissioning and Validation of 192Ir Brachytherapy Model-Based Dose Calculation Software

Authors

  • Ma Y,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Vijande J,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Ballester F,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
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  • Tedgren Asa Carlsson,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Granero D,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Haworth A,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Mourtada F,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Fonseca G,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Zourari K,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Papagiannis P,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Rivard M,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Siebert F,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Sloboda R,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Smith R,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Thomson R,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Verhaegen F,

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author
  • Beaulieu L

    1. CHU de Quebec, Quebec, QC
    2. University of Valencia, Burjassot
    3. University of Valencia, Burjassot
    4. Linkoping Univ, Linkoping
    5. ERESA-Hospital General Universitario, Mislata
    6. Peter MacCallum Cancer Centre, Vic Australia
    7. Christiana Care Hospital, Newark, DE
    8. Instituto de Pesquisas Energeticas e Nucleares IPEN-CNEN/SP, Sao Paulo, Maastricht
    9. Medical Physics Laboratory, Medical School, University of Athens, Athens, Athens
    10. Univ Athens, Athens
    11. Tufts Univ. School Med., Boston, MA
    12. Clinic of Radiotherapy (Radiooncology), Kiel
    13. Cross Cancer Institute, Edmonton, AB
    14. St. Thomas Hospital, Nashville, TN
    15. Carleton Univ, Ottawa, ON
    16. Maastro Clinic, Maastricht
    17. Centre Hospitalier Univ de Quebec, Quebec, QC
    Search for more papers by this author

Abstract

Purpose:

Previously, generic HDR 192Ir source and shielded applicator were designed by WG- MBDCA, the AAPM-ESTRO-ABG Working Group on model-based dose calculation algorithms. TPS vendors have incorporated both into their TPS. A charge of WG-MBDCA is to develop a limited number of well-defined test cases and perform MBDCA dose calculations and comparisons. Here, we describe the test cases proposed, the 3D dosimetric data generation process and the 3D gamma analysis performed.

Methods:

A voxelized phantom of 512×512×512 voxels (HU=-1024,Air), with each voxel being 1×1×1 mm3, containing a concentric cubic contour structure (HU=0,Water) of dimension 201×201×201 voxels, was created in the DICOM- RT format. Three configurations were tested: i) source located at the center with surrounding structure assigned to water to mimic TG-43 conditions, ii) source displaced +7 cm along the × axis, iii) source located at the center with the shielded applicator in place. Advanced Collapsed-cone Engine (ACE, Elekta) and AcurosBV (Varian) were benchmarked. Reference datasets were independently produced by different groups using BrachyDose (1010 photons), GEANT4(4×1010), Penelope (2×1010), MCNP5(2 x1010), MCNP6(1011), and ALGEBRA(4×1010) Monte Carlo (MC) dose calculation platforms.

Results:

For the three configurations, MC agreed within 1% for the volume bounded by the 1% isodose surface; MCNP6 data sets were designated as reference (statistical error < 0.2% across the phantom). A 2%/1mm 3D γ- index criteria was used, within the volume bounded by 5% isodose surface, to account for both dose difference and source placement errors in TPS. Voxel pass rates were 95.2%, 99.5% and 90% for ACE and 98%, 98.4% and 95.9% for AcurosBV, respectively.

Conclusion:

The evaluated test cases are suitable for MBDCA QA. DICOM-RT files are being integrated into the joint AAPM/IROC Houston registry to support end-user TPS software commissioning.

Ancillary