Sci-Fri AM: MRI and Diagnostic Imaging - 01: Estimating the Transverse Relaxation Time of Taurine Protons in Rat Brain at 9.4 T with Optimized PRESS Sequence Timings

Authors

  • Fisher Marissa,

    1. University of Alberta, University of Alberta, Cross Cancer Institute and University of Alberta, Cross Cancer Institute and University of Alberta
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  • Dobberthien Brennen,

    1. University of Alberta, University of Alberta, Cross Cancer Institute and University of Alberta, Cross Cancer Institute and University of Alberta
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  • Tessier Anthony,

    1. University of Alberta, University of Alberta, Cross Cancer Institute and University of Alberta, Cross Cancer Institute and University of Alberta
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  • Yahya Atiyah

    1. University of Alberta, University of Alberta, Cross Cancer Institute and University of Alberta, Cross Cancer Institute and University of Alberta
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Abstract

Purpose:

To investigate the response of taurine (Tau) protons as a function of PRESS echo times, TE1 and TE2, to determine two TE combinations that can be employed to estimate the T2 (transverse relaxation) value of Tau at 9.4 T. The Tau protons are involved in J-coupling interactions; therefore, the two timing combinations should result in similar signal losses due to J-coupling.

Methods:

Experiments were performed with a 9.4 T animal MRI scanner. Numerical calculations of the response of Tau as a function of PRESS TE1 and TE2 were calculated and two TE combinations that yield a similar area for the 3.42 ppm Tau resonance were selected as optimal. The timings were verified on a 50 mM Tau/10 mM Cr (creatine) phantom. In-vivo experiments were performed on four rats. Spectra were acquired with the timings from a voxel placed in the rat brain and Tau peak areas were fit to monoexponentially decaying functions to obtain T2 values.

Results:

The PRESS TE combinations selected for Tau T2 determination are {TE1, TE2} = {17 ms, 10 ms} and {80 ms, 70 ms}; the signal yield for the two timings differs by 5 % theoretically. The average Tau T2 for the four rats was found to be 106 ms with a standard deviation of 12 ms.

Conclusions:

We have demonstrated that acquiring PRESS spectra with {TE1, TE2} = {17 ms, 10 ms} and {TE1, TE2} = {80 ms, 70 ms} enables T2 corrected measures of Tau to be obtained at 9.4 T.

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